Perturbation of differentiated functions during viral infection in vivo. II. Viral reassortants map growth hormone defect to the S RNA of the lymphocytic choriomeningitis virus genome.
Perturbation of differentiated functions during viral infection in vivo. II. Viral reassortants map growth hormone defect to the S RNA of the lymphocytic choriomeningitis virus genome.
复制标题
体内病毒感染过程中分化功能的扰动。
DOI：
10.1016/0042-6822(85)90431-3
复制
发表时间：
1985
期刊：
影响因子：
3.7
通讯作者：
Oldstone,MB
中科院分区：
文献类型：
--
作者：
Riviere,Y;Ahmed,R;Southern,P;Oldstone,MB
淋巴细胞性脉络丛脑膜炎病毒（LCMV）阿姆斯特朗引起的生长激素缺乏症继发于感染C3 H/St小鼠的生长和葡萄糖代谢紊乱。相比之下，LCMV株WE在较少的生长激素产生细胞中复制，未能破坏生长激素合成，并且在感染的匹配对照中不会引起生长激素诱导的疾病。本文报道了LCMV：Armstrong强毒株与LCMV：WE弱毒株之间的遗传互作。在C3 H/St小鼠中使用这些抑制剂和两种亲本病毒株，生长激素合成的扰动被清楚地定位到LCMV：ARM的S RNA片段。
Lymphocytic choriomeningitis virus (LCMV) Armstrong caused disordered growth and glucose metabolism secondary to growth hormone deficiency in infected C3H/St mice. In contrast, LCMV strain WE replicated in fewer growth hormone-producing cells, failed to disrupt growth hormone synthesis, and did not cause growth hormone-induced disease in infected, matched controls. The generation of genetic reassortant viruses between the virulent strain of LCMV:Armstrong and the avirulent strain, LCMV:WE, is reported. Using such reassortants and both parental strains of virus in C3H/St mice, the perturbation of growth hormone synthesis was clearly mapped to the S RNA segment of LCMV:ARM.