MEASURING AND ESTIMATING THE BIOCONCENTRATION FACTOR OF CHEMICALS IN FISH
MEASURING AND ESTIMATING THE BIOCONCENTRATION FACTOR OF CHEMICALS IN FISH
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DOI：
10.1139/f79-146
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发表时间：
1979-01-01
期刊：
影响因子：
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通讯作者：
BERGSTEDT, BV
中科院分区：
文献类型：
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作者：
VEITH, GD;DEFOE, DL;BERGSTEDT, BV
本文介绍了一种估算黑头鲦鱼（Pimephales promelas）体内有机化学物质生物浓度因子的方法。25度的水。C在一个流动水族箱中间歇性地服用无毒浓度的化学物质。将米诺鱼[30]放入水族箱中，在暴露2、4、8、16、24、32天后取出5条鱼的复合样本进行分析。利用一阶吸收模型总结了生物富集过程，并根据32天的暴露计算了稳态生物富集因子。生物浓缩系数（BCF）与单个化学物质的正辛醇/水分配系数(P)之间的结构-活性相关性可以总结为log BCF = 0.85 log P - 0.70，该方程允许在实验室测试前估计化学物质的生物浓缩系数在60%以内。用于测试的设施和资源只需要用于那些可能在生物体中造成大量生物浓缩的化学品。从化学品混合物试验中得出的生物浓缩系数与单独使用化学品试验得出的生物浓缩系数相同。
A method of estimating the bioconcentration factor of organic chemicals in fathead minnows (Pimephales promelas) is described. Water at 25.degree. C was intermittently dosed with the chemical at a nontoxic concentration in a flow-through aquarium. Minnows [30] are placed in the aquarium, and composite samples of 5 fish are removed for analysis after 2, 4, 8, 16, 24, and 32 days of exposure. The bioconcentration process is summarized by using the 1st-order uptake model, and the steady-state bioconcentration factor is calculated from the 32-day exposure. A structure-activity correlation between the bioconcentration factor (BCF) and the n-octanol/water partition coefficient (P) of individual chemicals is summarized by the equation log BCF = 0.85 log P - 0.70, which permits the estimation of the bioconcentration factor of chemicals to within 60% before laboratory testing. The facilities and resources for testing need only be used for those chemicals that are likely to result in substantial bioconcentration in organisms. The bioconcentration factors derived from tests of mixtures of chemicals are the same as those derived from tests with the chemicals individually.