Survival in overweight and underweight children undergoing hematopoietic stem cell transplantation
Survival in overweight and underweight children undergoing hematopoietic stem cell transplantation
复制标题
DOI：
10.1038/ejcn.2012.109
复制
发表时间：
2012-10
影响因子：
4.7
通讯作者：
M. White;A. Murphy;A. Hallahan;R. Ware;C. Fraser;P. Davies
中科院分区：
文献类型：
--
作者：
M. White;A. Murphy;A. Hallahan;R. Ware;C. Fraser;P. Davies
结果：113例患者中，15例(13%)体重不足，41例(36%)超重。在调整了年龄、性别、供体来源、调理治疗和移植年份后，超重患者存活的可能性明显低于理想体重患者(风险比(HR)1.91；95%可信区间1.10-3.31)。与理想体重儿童相比，体重不足患者的死亡率没有显著增加(HR 1.47；95%可信区间0.57-3.79)。结论：造血干细胞移植前超重儿童的存活率低于理想体重儿童。
Results:Of 113 patients, 15 (13%) were underweight and 41 (36%) were classified as overweight. After adjustment for age, sex, donor source, conditioning therapy and year of transplant, overweight patients were significantly less likely to survive than ideal-weight patients (hazard ratio (HR) 1.91; 95% confidence interval, 1.10–3.31). There was no significant increase in mortality when underweight patients were compared with ideal-weight patients (HR 1.47; 95% confidence interval, 0.57–3.79).Conclusions:Children who are overweight before hematopoietic stem cell transplantation have decreased survival compared with ideal-weight children.