HLA matching: maximizing the number of compatible transplants.
HLA matching: maximizing the number of compatible transplants.
复制标题
HLA匹配：最大化兼容移植的数量。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
P. Terasaki
中科院分区：
文献类型：
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作者：
S. Takemoto;D. Gjertson;P. Terasaki
1. Less than 10% of the cadaver kidneys currently allocated have 0-B,DR mismatches. 2. Up to 15% of the kidneys could be regionally allocated using the UNOS algorithm to 0-B,DR-mismatched recipients with a projected 67% 5-year graft survival. 3. Twice the number (32%) of recipients can be identified with zero of 10 A,B residues mismatched with the same 67% 5-year survival. 4. Another doubling (68%) of compatible recipients can be identified with zero of 7 DR supertypic determinants (4 DQ and 3 DRB) and zero of the A,B residues mismatched with a 66% 5-year graft survival. 5. Compressing A,B, and DR antigens to supertypic determinants reduces the racial differences in HLA to the point that 90% of kidneys can be allocated to Black recipients with zero of 3 DRB and zero A,B residues mismatched.
