Palladium-Catalyzed Remote Aryldifluoroalkylation of Alkenyl Aldehydes
Palladium-Catalyzed Remote Aryldifluoroalkylation of Alkenyl Aldehydes
复制标题
钯催化烯基醛的远程芳基二氟烷基化
DOI：
10.1002/anie.201611697
复制
发表时间：
2017
影响因子：
16.6
通讯作者：
Zhu Gangguo
中科院分区：
文献类型：
--
作者：
Nie Xingliang;Cheng Cungui;Zhu Gangguo
在钯的催化下，氟烷基溴化物、芳基硼酸和烯基醛之间的三组分反应已经被开发出来，并提供了在非常温和的反应条件下容易地获得5-，6-或7-二氟烷基酮的方法。银催化的5-芳基-2，2-二氟戊酸分子内脱羧环反应可以顺利地将产物转化为含CF2的四氢萘。
A palladium‐catalyzed three‐component reaction between fluoroalkyl bromides, arylboronic acids, and alkenyl aldehydes has been developed and provides facile access to 5‐, 6‐, or 7‐difluoroalkylated ketones under very mild reaction conditions. The resultant products can be smoothly converted into CF2‐containing tetrahydronaphthalenes by a novel silver‐catalyzed intramolecular decarboxylative cyclization of 5‐aryl‐2,2‐difluoropentanoic acids.