Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer.
Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer.
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胰岛素样生长因子-I (IGF-I) 和 IGF 结合蛋白-3 作为晚期前列腺癌的预测因子。
DOI：
10.1093/jnci/94.14.1099
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Giovannucci,Edward
中科院分区：
文献类型：
--
作者：
Chan,JuneM;Stampfer,MeirJ;Ma,Jing;Gann,Peter;Gaziano,JMichael;Pollak,Michael;Giovannucci,Edward
背景：血浆胰岛素样生长因子-I (IGF-I) 水平与前列腺癌的风险相关。然而，IGF-I 与特定肿瘤分期和诊断分级的关系（与复发和死亡风险相关）尚未经过严格研究。为了确定 IGF-I 及其主要循环结合蛋白 IGF 结合蛋白-3 (IGFBP-3) 的血浆水平是否可以预测前列腺癌更具侵袭性的形式，我们研究了前列腺癌的每个特定阶段和级别的血浆水平之间的关联。方法：我们在前瞻性医生健康研究中的一项巢式病例对照研究中检查了 530 名病例患者和 534 名对照受试者。 1982 年至 1995 年间诊断出的前列腺癌患者与对照受试者按年龄和吸烟状况进行匹配。在前瞻性收集的血浆样本中测量 IGF-I 和 IGFBP-3。使用条件逻辑回归模型来估计与 IGF-I 和 IGFBP-3 相关的前列腺癌的相对风险 (RR)，按级别（格里森评分≥7 与 <7）和分期（早期 = A 或 B 期前列腺癌与晚期 = C 或 D 期前列腺癌）分层。所有统计检验均为双向。结果：IGF-I 和 IGFBP-3 的血浆水平是晚期前列腺癌的预测因子（对于 IGF-I 最高四分位数与最低四分位数，RR = 5.1，95% 置信区间 [CI] = 2.0 至 13.2；对于 IGFBP-3 最高四分位数与最低四分位数，RR = 0.2，95% CI = 0.1 至 0.6），但不是早期前列腺癌。两者都与格里森评分没有差异相关。与 IGF-I 水平高和 IGFBP-3 水平低的男性相比，IGF-I 水平高和 IGFBP-3 水平低的男性患晚期前列腺癌的 RR 为 9.5（95% CI = 1.9 至 48.4）。与单独测量 PSA 相比，将 IGF-I 和 IGFPB-3 测量与标准前列腺特异性抗原 (PSA) 测量相结合进行前列腺癌筛查增加了特异性（从 91% 至 93%），但敏感性降低（从 40% 至 36%）。结论：IGF-I 和 IGFBP-3 的循环水平可以预测患晚期前列腺癌的风险，但它们在筛查前列腺癌患者中的效用可能有限。
Background:Plasma levels of insulin-like growth factor-I (IGF-I) have been associated with the risk of prostate cancer. However, the association of IGF-I with specific tumor stage and grade at diagnosis, which correlate with risk of recurrence and mortality, has not been studied rigorously. To determine whether plasma levels of IGF-I and its main circulating binding protein, IGF binding protein-3 (IGFBP-3), predict more aggressive forms of prostate cancer, we investigated the association between plasma levels of each and specific stages and grades of prostate cancer.Methods:We examined 530 case patients and 534 control subjects in a nested case–control study in the prospective Physicians' Health Study. Patients with prostate cancer diagnosed from 1982 through 1995 were matched to control subjects by age and smoking status. IGF-I and IGFBP-3 were measured in prospectively collected plasma samples. Conditional logistic regression models were used to estimate the relative risks (RRs) for prostate cancer associated with IGF-I and IGFBP-3, stratified on grade (Gleason score ≥7 versus <7) and stage (early = stage A or B prostate cancer versus advanced = stage C or D prostate cancer). All statistical tests were two-sided.Results:Plasma levels of IGF-I and IGFBP-3 were predictors of advanced-stage prostate cancer (RR = 5.1, 95% confidence interval [CI] = 2.0 to 13.2 for highest versus lowest quartiles of IGF-I; RR = 0.2, 95% CI = 0.1 to 0.6 for highest versus lowest quartiles of IGFBP-3) but not of early-stage prostate cancer. Neither was differentially associated with Gleason score. Men with high IGF-I levels and low IGFBP-3 levels had an RR for advanced-stage prostate cancer of 9.5 (95% CI = 1.9 to 48.4) compared with men with low levels of both. Combining IGF-I and IGFPB-3 measurements with a standard prostate-specific antigen (PSA) measurement for prostate cancer screening increased the specificity (from 91% to 93%) but decreased sensitivity (from 40% to 36%) compared with measurement of PSA alone.Conclusions:Circulating levels of IGF-I and IGFBP-3 may predict the risk of developing advanced-stage prostate cancer, but their utility for screening patients with incident prostate cancer may be limited.
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DOI：
--
发表时间：
1999
期刊：
--
影响因子：
--
作者：
J. Masters;B. Palsson
通讯作者：
J. Masters;B. Palsson
DOI：
10.1093/jnci/92.23.1910
发表时间：
2000-12-06
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Stattin, P;Bylund, A;Kaaks, R
通讯作者：
Kaaks, R
影响因子：
5.8
作者：
COHEN, P;PEEHL, DM;ROSENFELD, RG
通讯作者：
ROSENFELD, RG
血清胰岛素样生长因子-1 不是前列腺癌的有用标志物
影响因子：
4.5
作者：
Cutting;Hunt;Nisbet;Bland;Dalgleish;Kirby
通讯作者：
Kirby
用于前列腺癌检测的胰岛素样生长因子 1 (IGF-1)、IGF-1 密度和 IGF-1/PSA 比率。
影响因子：
2.1
作者：
B. Djavan;B. Bursa;C. Seitz;G. Soeregi;M. Remzi;A. Basharkhah;R. Wolfram;M. Marberger
通讯作者：
M. Marberger