Transforming growth factor β in hypertensives with cardiorenal damage
Transforming growth factor β in hypertensives with cardiorenal damage
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DOI：
10.1161/01.hyp.36.4.517
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发表时间：
2000-10-01
期刊：
影响因子：
8.3
通讯作者：
Díez, J
中科院分区：
文献类型：
--
作者：
Laviades, C;Varo, N;Díez, J
我们研究了循环转化生长因子β-1(1)、I型胶原代谢、微量白蛋白尿和高血压患者左室肥厚之间是否存在关系，以及血管紧张素II 1型受体拮抗剂氯沙坦纠正高血压患者微量白蛋白尿和逆转左室肥厚的能力是否与转化生长因子-β(1)和I型胶原代谢的变化有关。30例血压正常的健康人和30例未经治疗的高血压病患者分为两组：微量白蛋白尿伴左室肥厚(男116g/m(2)，女104g/m(2))(B组，n=17)；无微量白蛋白尿或左室肥厚(A组，n=13)。所有患者在服用氯沙坦(每天一次，每次50毫克)治疗6个月后重复测量。用双抗体夹心法测定血清转化生长因子-β(1)浓度，用放射免疫法测定I型胶原合成标志物I型前胶原羧基末端多肽和I型胶原降解标志物I型胶原羧基末端多肽的浓度。两组患者的高血压病程和血压基线值相似。正常血压组与高血压组之间血清转化生长因子-β(1)、I型前胶原羧基末端多肽、I型胶原羧基末端多肽无明显差异。血清转化生长因子-β(1)、I型前胶原羧基末端多肽、I型前胶原羧基末端多肽/I型胶原羧基末端多肽比值升高(P
We investigated whether a relationship exists between circulating transforming growth factor beta -1 (TGF-beta (1)), collagen type I metabolism, microalbuminuria, and left ventricular hypertrophy in essential hypertension and whether the ability of the angiotensin II type 1 receptor antagonist losartan to correct microalbuminuria and regress left ventricular hypertrophy in hypertensives is related to changes in TGF-beta (1) and collagen type I metabolism. The study was performed in 30 normotensive healthy controls and 30 patients with never-treated essential hypertension classified into 2 groups: those with microalbuminuria (urinary albumin excretion > 30 and < 300 mg/24 h) associated with left ventricular hypertrophy (left ventricular mass index > 116 g/m(2) for men and > 104 g/m(2) for women) (group B; n=17) and those without microalbuminuria or left ventricular hypertrophy (group A; n=13). The measurements were repeated in all patients after 6 months of treatment with losartan (50 mg once daily). The serum concentration of TGF-beta (1) was measured by a 2-site ELISA method, and the serum concentrations of carboxy-terminal propeptide of procollagen type I (a marker of collagen type I synthesis) and carboxy-terminal telopeptide of collagen type I (a marker of collagen type I degradation) were measured by specific radioimmunoassays. The duration of hypertension and baseline values of blood pressure were similar in the 2 groups of patients. No differences in serum TGF-beta (1), carboxy-terminal propeptide of procollagen type I, and carboxy-terminal telopeptide of collagen type I were found between normotensives and group A of hypertensives. Serum TGF-beta (1), carboxy-terninal propeptide of procollagen type I, and the ratio of carboxy-terminal propeptide of procollagen type I to carboxy-terminal telopeptide of collagen type I were increased (P