An Improved System for the Aqueous Lipshutz-Negishi Cross-Coupling of Alkyl Halides with Aryl Electrophiles
An Improved System for the Aqueous Lipshutz-Negishi Cross-Coupling of Alkyl Halides with Aryl Electrophiles
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DOI：
10.1002/anie.201509341
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发表时间：
2016-01-26
影响因子：
16.6
通讯作者：
Buchwald, Stephen L.
中科院分区：
文献类型：
--
作者：
Bhonde, Vasudev R.;O'Neill, Brian T.;Buchwald, Stephen L.
以新型联芳（二烷基）膦配体（VPhos）为载体，辛酸/辛酸钠作为简单有效的表面活性剂体系，为原位生成烷基锌试剂快速构建广谱烷基化支架提供了一种改进的催化剂体系。
The development of a palladacyclic precatalyst supported by a new biaryl(dialkyl)phosphine ligand (VPhos) in combination with octanoic acid/sodium octanoate as a simple and effective surfactant system provided an improved catalyst system for the rapid construction of a broad spectrum of alkylated scaffolds from alkyl zinc reagents generated in situ.