HIV-1 DNA for the measurement of the HIV reservoir is predictive of disease progression in seroconverters whatever the mode of result expression is
HIV-1 DNA for the measurement of the HIV reservoir is predictive of disease progression in seroconverters whatever the mode of result expression is
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DOI：
10.1016/j.jcv.2008.03.013
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发表时间：
2008-08-01
影响因子：
8.8
通讯作者：
Rouzioux, Christine
中科院分区：
文献类型：
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作者：
Avettand-Fenoel, Veronique;Boufassa, Faroudy;Rouzioux, Christine
背景资料：HIV-1 DNA水平报告为拷贝数/10（6）个外周血单核细胞（PBMC），可非常准确地预测血清转换者的疾病进展，与CD 4（+）T细胞计数和HIV-RNA无关。在此之前，HIV-DNA水平有时会通过其他方式报告：拷贝数/10（6）CD 4（+）T细胞，反映感染细胞的比例;或拷贝数/mL全血，反映全球血液储备的大小。目的：我们调查了疾病自然病程的预测值是否取决于结果的报告方式。研究设计：对于法国SEROCO队列（ANRS）中的422名血清转换者，将报告为HIV-DNA拷贝数/10（6）PBMC的结果转换为拷贝数/10（6）CD 4（+）T细胞或拷贝数/mL全血。在血清转换期间的HIV-DNA的水平与疾病进展在所有三个reportingmethods.Conclusions：这加强了HIV-DNA定量的价值，在病理生理和治疗研究，特别是在一个时代的研究，旨在减少艾滋病毒水库。即使血液只占这一储存库的一小部分，血液中的HIV-DNA也是一个简单的标志物，可以提供全球储存库的信息，并强烈预测疾病的进展。(C)2008 Elsevier B. V.保留所有权利。
Background: HIV-1 DNA levels, reported as copies/10(6) peripheral blood mononuclear cells (PBMC), are very predictive of disease progression in seroconverters, independently of CD4(+)T cell count and HIV-RNA. Previously, HIV-DNA levels have sometimes been reported by other means: copies/10(6) CD4(+)T cells, reflecting the proportion of infected cells; or copies/mL whole blood, reflecting the global blood reservoir size.Objectives: We investigated if the predictive value over the natural course of the disease depends on how the results are reported.Study design: Results reported as HIV-DNA copies/10(6) PBMC were converted to Copies/10(6) CD4(+)T cells or to copies/mL whole blood for 422 seroconverters included in the French SEROCO cohort (ANRS).Results: The three methods for reporting HIV-DNA levels yielded different ranges, but these values were highly correlated. The level of HIV-DNA during the seroconversion period was strongly associated with disease progression in all three reporting methods.Conclusions: This reinforces the value of HIV-DNA quantification in physiopathological and therapeutical studies, particularly in an era of research aimed at diminishing the HIV reservoir. Even if blood represents a small part of this reservoir, HIV-DNA in blood is a simple marker that provides an informative picture of the global reservoir and is strongly predictive of disease progression. (C) 2008 Elsevier B.V. All rights reserved.