Emergence of G9 P[6] human rotaviruses in Argentina: Phylogenetic relationships among G9 strains
Emergence of G9 P[6] human rotaviruses in Argentina: Phylogenetic relationships among G9 strains
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DOI：
10.1128/jcm.39.11.4020-4025.2001
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发表时间：
2001-11-01
影响因子：
9.4
通讯作者：
Gomez, J
中科院分区：
文献类型：
--
作者：
Bok, K;Palacios, G;Gomez, J
由于轮状病毒腹泻可以通过接种疫苗来减少，而且目前的候选疫苗只针对最常见的G抗原型(G1至G4)提供保护，因此检测不常见的G型是轮状病毒监测的主要目标之一。在阿根廷一项为期两年的全国轮状病毒监测研究得出结论后，监测继续进行，并在阿根廷几个城市发现G9流行率上升。在此期间，G9株在南方占主导地位，并观察到从南到北G9流行呈递减趋势(41%至0%)。对编码G抗原的基因9的序列分析表明，阿根廷毒株与大多数来自其他国家的G9毒株聚在一起，核苷酸差异不到2%，但与它们不同的是，它们呈现出一些独特的氨基酸变化。我们的结果与世界其他地区G9流行率上升的报告一致，表明有必要将G9纳入候选轮状病毒疫苗。
Because rotavirus diarrhea can be reduced through vaccination and because current vaccine candidates provide protection against only the most common G antigenic types (G1 to G4), detection of uncommon G types is one of the main goals of rotavirus surveillance. After a 2-year nationwide rotavirus surveillance study in Argentina concluded, surveillance was continued and an increase of G9 prevalence in several Argentine cities was detected. During this period G9 strains predominated in the south, and a gradient of decreasing G9 prevalence was observed from south to north (41 to 0%). Sequence analysis of gene 9, encoding the G antigen, showed that Argentine strains cluster with most G9 isolates from other countries, showing less than 2% nucleotide divergence among them, but are distinctive from them in that they present some unique amino acid changes. Our results agree with reports of increased G9 prevalence in other parts of the world, suggesting the need to incorporate G9 into candidate rotavirus vaccines.