Neural Transplantation in Spinal Cord under Different Conditions of Lesions and Their Functional Significance
Neural Transplantation in Spinal Cord under Different Conditions of Lesions and Their Functional Significance
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不同病变条件下脊髓神经移植及其功能意义
DOI：
10.1007/978-3-662-25264-2_1
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
G. D. Das
中科院分区：
文献类型：
--
作者：
G. D. Das
脊髓损伤与再生问题的研究由来已久。这项研究的重要性在于，这一结构的创伤剥夺了个人对基本运动功能的自愿控制，如参与运动的肢体运动。创伤的严重程度和脊髓损伤的程度决定了运动功能丧失的性质和程度。了解创伤引起的病理事件的复杂性，功能丧失的性质和永久性，以及恢复失去的功能所固有的困难，一直是许多领域的研究人员关注的问题。病理学家、神经生物学家、神经胚胎学家和神经外科医生等在各自的领域内做出了相当大的贡献，解释了为什么在严重创伤后，没有功能恢复，并对如何实现功能恢复进行了不同的推测。在不同的时期，不同的研究人员声称，在手术或药物治疗后，丧失的运动功能恢复了。但这些说法无法得到其他独立调查人员的支持。因此，尽管在了解病理事件和受损纤维系统再生有限或不再生的问题上取得了很大进展，但恢复失去的运动功能的目标仍然遥不可及。
Research on the problems of trauma and regeneration in the spinal cord has a long history. The importance of this research lies in the fact that trauma to this structure deprives the individual of voluntary control over the basic motor functions, such as movement of limbs involved in locomotion. The severity of trauma and the level of spinal cord where it is inflicted determine the nature and magnitude of loss of motor functions. Understanding the complexity of pathological events ensuing from the trauma, the nature and permanency of the functional loss, and the difficulties inherent in the restitution of the lost functions has been a concern for investigators in many fields. Pathologists, neuro-biologists, neuroembryologists, and neurosurgeons, among others, have contributed to a considerable extent within their respective domains towards explaining why, following a serious trauma, there is no functional recovery, and have speculated variously on how to achieve it. At different periods, various investigators claimed recovery of lost locomotor functions following surgical or pharmacological treatments. But those claims could not be supported by other investigators working independently. Thus, despite the great progress made towards an understanding of the pathological events and the problems of limited or no regeneration of damaged fiber systems, the goal of achieving recovery of the lost motor functions has remained beyond our reach.