2,4,5-Trichlorophenoxyacetic acid inhibits apoptosis in PC12 cells.
2,4,5-Trichlorophenoxyacetic acid inhibits apoptosis in PC12 cells.
复制标题
2,4,5-三氯苯氧基乙酸抑制 PC12 细胞凋亡。
DOI：
10.1016/s0024-3205(01)01132-8
复制
发表时间：
2001
期刊：
影响因子：
6.1
通讯作者：
M. Kurasaki
中科院分区：
文献类型：
--
作者：
Osamu Yamanoshita;T. Saito;Kyoko Takahashi;T. Hosokawa;Masashi Okabe;Keizo Ito;M. Kurasaki
2，4，5-三氯苯氧乙酸（2，4，5-T）是一种内分泌干扰物，对生物体具有细胞毒性作用。本研究探讨了低浓度2，4，5-T对PC 12细胞凋亡的影响。虽然2，4，5-T处理的PC 12细胞没有观察到凋亡特征，但它抑制了血清剥夺诱导的DNA片段化。另外，2，4，5-T处理后，PC 12细胞的存活率明显提高。结论：2，4，5-T可抑制体外培养的细胞凋亡。由于细胞凋亡是细胞死亡的生理机制的形态学和生物化学描述，通常与个体和器官发育所必需的程序性事件相关，因此2，4，5-T对细胞凋亡的抑制作用可能会严重损害细胞的稳态和分化。
2,4,5-Trichlorophenoxyacetic acid (2,4,5-T) is an endocrine disrupter that exerts cytotoxic effects on organisms. In this study, the influence of 2,4,5-T at low concentrations on apoptosis in PC12 cells was investigated. Although no apoptotic features were observed in PC12 cells treated with 2,4,5-T, it inhibited the DNA fragmentation induced by serum deprivation. In addition, the cell viability of PC12 cells increased after treatment with 2,4,5-T. In conclusion, 2,4,5-T suppressed the apoptosis of the cultured cells. Since apoptosis is a morphological and biochemical description of a physiological mechanism of cell death that is commonly associated with programmed events necessary for development of individuals and organs, the inhibitory effect of 2,4,5-T on apoptosis might cause serious damage to cell homeostasis and differentiation.