Involvement of dendritic adhesion molecule telencephalin in hippocampal long-term potentiation
Involvement of dendritic adhesion molecule telencephalin in hippocampal long-term potentiation
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DOI：
10.1097/00001756-199803300-00022
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发表时间：
1998-03-30
期刊：
影响因子：
1.7
通讯作者：
Mori, K
中科院分区：
文献类型：
--
作者：
Sakurai, E;Hashikawa, T;Mori, K
端脑蛋白（TLCN）是属于免疫球蛋白超家族的细胞粘附分子，其表达限于最高度发育的脑节段端脑内的神经元。免疫电镜观察发现，在海马CA 1区，TLCN定位于锥体细胞树突的突触后棘的表面膜，而不在轴突终末的表面膜。使用抗TLCN抗体或重组可溶性TLCN蛋白阻断TLCN功能引起Schaffer侧支-CA 1突触的长时程增强（LTP）显著抑制。即使在强直刺激后立即开始阻断时也观察到抑制。这些观察结果表明TLCN介导的细胞间相互作用是LTP发展的关键步骤。(C)1998 Rapid Science Ltd.
TELENCEPHALIN (TLCN) is a cell adhesion molecule belonging to the immunoglobulin superfamily whose expression is restricted to neurons within the most highly developed brain segment, telencephalon. Immunoelectronmicroscopic study revealed that in the hippocampal CA1 region, TLCN was localized at the surface membrane of postsynaptic spines of pyramidal cell dendrites but not at that of axonal terminals. Blocking of TLCN function using anti-TLCN antibody or recombinant soluble TLCN protein caused a striking suppression of the long-term potentiation (LTP) at the Schaffer collateral-CA1 synapses. The suppression was observed even when the blocking was initiated immediately after the tetanic stimuli. These observations suggest a role for TLCN-mediated cell-cell interactions as a key step in the development of LTP. (C) 1998 Rapid Science Ltd.