Tumor-associated macrophages contribute to tumor progression in ovarian cancer.
Tumor-associated macrophages contribute to tumor progression in ovarian cancer.
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DOI：
10.3389/fonc.2014.00137
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发表时间：
2014
影响因子：
4.7
通讯作者：
Colvin EK
中科院分区：
文献类型：
--
作者：
Colvin EK
卵巢癌是妇科恶性肿瘤妇女死亡的主要原因，需要改进目前的治疗方法。与许多其他实体癌一样，卵巢肿瘤微环境正在成为肿瘤进展的关键参与者和潜在的治疗靶点。肿瘤微环境包含几种已知有助于肿瘤进展和转移的非恶性细胞类型。在这个非恶性细胞群体中包括几种不同类型的免疫细胞，其中肿瘤相关巨噬细胞（TAM）是最丰富的。越来越多的证据表明，TAMs在卵巢肿瘤中表现出独特的激活特征，并且能够创造一个免疫抑制微环境，使肿瘤逃避免疫检测并促进肿瘤进展。因此，进一步了解这些免疫细胞如何与肿瘤细胞和微环境相互作用，将大大有助于开发更有效的免疫疗法来治疗卵巢癌。本文综述了TAM在卵巢肿瘤微环境中的作用以及它们如何促进肿瘤进展。
Ovarian cancer is the leading cause of death in women with gynecological malignancy and improvements in current treatments are needed. As with many other solid cancers, the ovarian tumor microenvironment is emerging as a key player in tumor progression and a potential therapeutic target. The tumor microenvironment contains several non-malignant cell types that are known to contribute to tumor progression and metastasis. Included in this population of non-malignant cells are several different types of immune cells, of which tumor-associated macrophages (TAMs) are the most abundant. An increasing amount of evidence is emerging to suggest that TAMs display a unique activation profile in ovarian tumors and are able to create an immunosuppressive microenvironment, allowing tumors to evade immune detection and promoting tumor progression. Therefore, an increased understanding of how these immune cells interact with tumor cells and the microenvironment will greatly benefit the development of more effective immunotherapies to treat ovarian cancer. This review focuses on the role of TAMs in the ovarian tumor microenvironment and how they promote tumor progression.