HUMAN APOLIPOPROTEIN-A-I GENE-EXPRESSION INCREASES HIGH-DENSITY-LIPOPROTEIN AND SUPPRESSES ATHEROSCLEROSIS IN THE APOLIPOPROTEIN E-DEFICIENT MOUSE
HUMAN APOLIPOPROTEIN-A-I GENE-EXPRESSION INCREASES HIGH-DENSITY-LIPOPROTEIN AND SUPPRESSES ATHEROSCLEROSIS IN THE APOLIPOPROTEIN E-DEFICIENT MOUSE
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DOI：
10.1073/pnas.91.20.9607
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发表时间：
1994-09-27
影响因子：
11.1
通讯作者：
BRESLOW, JL
中科院分区：
文献类型：
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作者：
PLUMP, AS;SCOTT, CJ;BRESLOW, JL
动脉粥样硬化是一种复杂的疾病，具有遗传和环境决定因素。载脂蛋白 (Apo) E 缺陷小鼠已被培育出来，它们非常容易患动脉粥样硬化。为了评估人载脂蛋白（hApo）A-I和高密度脂蛋白（HDL）在动脉粥样硬化易感性中的作用，将过表达hApo A-I基因的转基因小鼠与Apo E缺陷小鼠杂交。 HDL 胆固醇升高两倍的 Apo E -/-、hApo A-I 小鼠在 8 个月大时，动脉粥样硬化明显减少，纤维增生性病变减少。 HDL 胆固醇水平与动脉粥样硬化之间存在很强的相互关系，HDL 水平占观察到的平均病变面积方差的 78%。 HDL 对动脉粥样硬化抵抗的作用与非 HDL 胆固醇无关。
Atherosclerosis is a complex disease with both genetic and environmental determinants. Apolipoprotein (Apo) E-deficient mice have been created that are highly susceptible to atherosclerosis. In order to assess the role of human apolipoprotein (hApo) A-I and high density lipoprotein (HDL) in atherosclerosis susceptibility, transgenic mice overexpressing the hApo A-I gene were crossed with Apo E-deficient mice. Apo E -/-, hApo A-I mice with two fold elevation in HDL cholesterol have markedly diminished atherosclerosis with less fibroproliferative lesions by 8 months of age. A strong reciprocal relationship between HDL cholesterol levels and atherosclerosis was found with HDL levels accounting for 78% of the observed variance in mean lesion area. The effect of HDL on atherosclerosis resistance was independent of non-HDL cholesterol.