Interactions of drebrin and gephyrin with profilin
Interactions of drebrin and gephyrin with profilin
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DOI：
10.1006/bbrc.1997.8068
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发表时间：
1998-02-04
影响因子：
3.1
通讯作者：
Takai, Y
中科院分区：
文献类型：
--
作者：
Mammoto, A;Sasaki, T;Takai, Y
Profilin是一种肌动蛋白单体结合蛋白，可刺激肌动蛋白聚合。最近的研究表明，profilin与VASP、Mena、Bni 1 p、Bnr 1 p和mDia相互作用，所有这些都具有富含脯氨酸的结构域。在这里，我们分离出三个profilin结合蛋白从大鼠脑细胞质中的谷胱甘肽S-转移酶profilin亲和柱层析，并确定为Mena，drephyrin，和gephyrin。这些蛋白质具有富含脯氨酸的结构域，并直接与profilin相互作用。(C)北京：科学出版社.
Profilin is an ac tin monomer-binding protein which stimulates actin polymerization. Recent studies have revealed that profilin interacts with VASP, Mena, Bni1p, Bnr1p, and mDia, all of which have the proline-rich domain. Here, we isolated three profilin-binding proteins from rat brain cytosol by glutathione S-transferase-profilin affinity column chromatography and identified them as Mena, drebrin, and gephyrin. These proteins had a proline-rich domain and directly interacted with profilin. (C) 1998 Academic Press.