Demonstration of active tolerance in maintenance of established islet of Langerhans allografts.
Demonstration of active tolerance in maintenance of established islet of Langerhans allografts.
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展示了朗格汉斯同种异体移植物维持已建立胰岛的主动耐受性。
DOI：
10.1073/pnas.79.13.4153
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发表时间：
1982
影响因子：
11.1
通讯作者：
Davie,J
中科院分区：
文献类型：
--
作者：
Faustman,D;Hauptfeld,V;Lacy,P;Davie,J
如果在移植前用抗 Ia 血清和补体处理胰岛，则可以通过移植来自组织不相容小鼠的朗格汉斯胰岛来逆转小鼠中链脲佐菌素诱导的糖尿病。在这里，我们表明，抗 Ia 处理的胰岛很可能在受体动物中诱导耐受。每天注射受体特异性抗 I-J 血清（移植后 80 天或更长时间开始）和少量供体脾细胞导致一半动物立即出现胰岛排斥反应；单独使用抗 I-J 血清和供体脾细胞均无效。这种处理后对已建立的同种异体移植物的排斥很可能是同种异体移植物特异性抑制细胞活性消除的结果。
Streptozotocin-induced diabetes in mice can be reversed by transplantation of islets of Langerhans from histoincompatible mice if the islets are treated with anti-Ia-serum and complement before transplantation. Here we show that anti-Ia-treated islets most likely induce tolerance in the recipient animals. Daily injections of recipient-specific anti-I-J-serum (beginning 80 or more days after transplantation) and small numbers of donor splenocytes caused the prompt rejection of the islets in half of the animals; neither anti-I-J-serum nor donor splenocytes alone were effective. It is likely that rejection of established allografts after this treatment is the result of abolition of the activity of allograft-specific suppressor cells.