Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival.
Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival.
复制标题
寻找Pyroposis-Modulating miRNAs作为改善肌萎缩症生存的治疗靶点。
DOI：
10.1155/2015/254871
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发表时间：
2015
影响因子：
4.6
通讯作者：
Hwang KC
中科院分区：
文献类型：
--
作者：
Lee S;Choi E;Cha MJ;Hwang KC
焦亡是最近发现的一种伴随炎症反应的调节性细胞死亡，具有不同于凋亡或坏死的特征。最近，独立的研究报告，小的非编码RNA称为microRNA（miRNA）参与调节焦亡。然而，目前只有少数关于miRNA依赖性调节细胞凋亡的经验数据可用。本文就miRNAs在心肌细胞凋亡中的作用进行综述，并为进一步研究miRNAs作为连接心肌细胞凋亡与各种心血管疾病（CVD）之间的纽带及其作为预防CVD期间心肌细胞过度死亡的治疗靶点提供建议。
Pyroptosis is the most recently identified type of regulated cell death with inflammatory response and has characteristics distinct from those of apoptosis or necrosis. Recently, independent studies have reported that small noncoding RNAs termed microRNAs (miRNAs) are involved in the regulation of pyroptosis. Nevertheless, only a handful of empirical data regarding miRNA-dependent regulation of pyroptosis is currently available. This review is aimed to provide a current update on the role of miRNAs in pyroptosis and to offer suggestions for future studies probing miRNAs as a linker connecting pyroptosis to various cardiovascular diseases (CVDs) and their potential as a therapeutic target for preventing excessive cell death of myocardium during CVDs.