High altitude-induced pulmonary arterial hypertension in the llama (Lama glama).
High altitude-induced pulmonary arterial hypertension in the llama (Lama glama).
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高海拔引起的美洲驼肺动脉高压（Lama glama）。
DOI：
10.1152/ajplegacy.1971.220.2.422
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
J. Will
中科院分区：
文献类型：
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作者：
N. Banchero;R. Grover;J. Will
班切罗、纳塔利奥、罗伯特·F·格罗弗和詹姆斯·A·威尔。高海拔引起的美洲驼肺动脉高压（Lama glama）。是。 J.生理学。 220（Z）：422-427。 1971.-三只雄性海平面美洲驼，分别是 5 个月（22.7 kg）、7 个月（31.8 kg）和 14 个月（59.0 kg），在 260 m 的高度以及 5 周和 10 周后在 3,420 m 的高度进行了研究。使用心导管插入术，在休息时、急性缺氧期间（PI o2 介于 72-78 mm Hg 之间）和跑步机运动期间进行测量。在高海拔地区还给出了100%02。每只动物的平均海平面静息肺动脉压 (Ppa) 为 14 mm Hg，并且显着增加。由于血流阻力增加，在 3,420 m 海拔 10 周后平均 ispa 为 23 mm Hg。海平面静息心输出量平均为每公斤 118 毫升/分钟，平均 (AV) 02 差异为 45.2 毫升/升。平均心输出量和 (AV) 02 差异在暴露于海拔高度时没有显着变化。美洲驼会出现与人类相同的中度肺动脉高压，但程度低于牛。有血管收缩的间接证据。肺循环；骆驼科；缺氧；锻炼;高氧;肺血管系统许多哺乳动物物种，包括人类，在高海拔地区居住期间都会出现肺动脉高压。不同物种肺动脉高压的程度不同，与缺氧刺激的大小即海拔高度有关。美洲驼（Lama glama）是骆驼科（Tylopoda）亚目的成员，原产于高海拔地区。它通常生活在安第斯山脉海拔3,000至4,500米的高原上。美洲驼可以忍受高海拔，没有明显的障碍。 Heath等人(8)基于解剖学考虑提出，原产于高海拔地区的美洲驼可能不会表现出肺动脉压力增加和肺血管阻力增加。
BANCHERO, NATALIO, ROBERT F. GROVER, AND JAMES A. WILL. High altitude-induced pulmonary arterial hypertension in the llama (Lama glama). Am. J. Physiol. 220 (Z): 422-427. 1971.-Three male sea-level llamas, 5 (22.7 kg), 7 (31.8 kg), and 14 (59.0 kg) months old were studied at 260 m and after 5 and 10 weeks at 3,420 m. Using heart catheterization, measurements were made at rest, during acute hypoxia (PI o2 between 72-78 mm Hg) and during treadmill exercise. At high altitude 100% 02 was also given. The average sea-level resting mean pulmonary artery pressure (Ppa) was 14 mm Hg and increased significantly in every animal. Average ispa was 23 mm Hg after 10 weeks at 3,420 m due to increased resistance to blood flow. The average sea-level resting cardiac output was 118 ml/min per kg and average (AV) 02 difference was 45.2 ml/liter. Average cardiac output and (AV) 02 difference did not change significantly on exposure to altitude. The llama develops a moderate degree of pulmonary arterial hypertension as seen in humans but less than that seen in cattle. There is indirect evidence of vasoconstriction. pulmonary circulation; Camelidae; hypoxia; exercise; hyperoxia; pulmonary vasculatureMANY MAMMALIAN SPECIES, including man, develop pulmonary arterial hypertension during residence at high altitude. The degree of the pulmonary hypertension varies in different species and it is related to the magnitude of the hypoxic stimulus, ie, the altitude level. The llama (Lama glama), a member of the Camelidae family, suborder Tylopoda, is indigenous to high altitude. It lives normally between 3,000 and 4,500 m in the high plateaus of the Andes. The llama tolerates high altitude with no apparent handicap. Heath et al.(8) have suggested, based on anatomical considerations, that the llama native to high altitude may not exhibit increased pulmonary artery pressure and increased pulmonary vascular resistance.