Grinding and granulation in a vibratory ball mill
Grinding and granulation in a vibratory ball mill
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DOI：
10.1016/0032-5910(81)87015-5
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发表时间：
1981
影响因子：
5.2
通讯作者：
I. Krycer;J. A. Hersey
中科院分区：
文献类型：
--
作者：
I. Krycer;J. A. Hersey
在振动球磨机中研磨对乙酰氨基酚、乳糖和蔗糖时，发现由于研磨颗粒的附聚而迅速达到平衡。在文献中已经广泛报道了这种团聚相的存在。本研究探讨延长振动球磨作为一种手段，药物造粒。颗粒由非常细的颗粒的附聚产生，并且随着粉碎的进行而变得更加致密。
In the grinding of paracetamol, lactose and sucrose in a vibratory ball mill, it is found that an equilibrium is rapidly attained due to the agglomeration of ground particles. The existence of this agglomerative phase of comminution has been extensively reported in the literature. This study investigates prolonged vibratory ball milling as a means of pharmaceutical granulation. The granules are produced from the agglomeration of very fine particles and become more compacted as comminution proceeds.