Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months
Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months
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DOI：
10.1002/term.299
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发表时间：
2011-02-01
影响因子：
3.3
通讯作者：
Ohgushi, Hajime
中科院分区：
文献类型：
--
作者：
Wakitani, Shigeyuki;Okabe, Takahiro;Ohgushi, Hajime
在自体体干细胞中，骨髓源性间充质干细胞（BMSCs）是全世界最广泛使用的，不仅用于修复间充质组织（骨、软骨），而且用于修复许多其他类型的组织，包括心脏、皮肤和肝脏。自体骨髓间充质干细胞被认为是安全的，因为没有免疫反应和疾病传播。然而，在长期随访期间，它们可能会形成肿瘤。1988年，我们移植自体骨髓间充质干细胞修复关节软骨，这是有史以来第一次报道的此类试验。随后，我们在大约40名患者中进行了该手术。这些患者既没有出现部分感染，也没有出现肿瘤，这为自体BMSC移植的安全性提供了强有力的证据。因此，在这项研究中，我们检查了这些患者的肿瘤发展和感染。1998年1月至2008年11月，41名患者接受了45次移植。我们查了他们上次来之前的记录。我们通过电话或邮件联系那些最近没有到诊所就诊的患者，以确定手术关节是否有任何异常。在5至137个月（平均75个月）的随访期间，未观察到肿瘤或感染。自体骨髓间充质干细胞移植是一种安全的方法，将在世界范围内广泛应用。版权所有（C）2010约翰威利父子有限公司
Among autologous somatic stem cells, bone marrow-derived mesenchymal stem cells (BMSCs) are the most widely used worldwide to repair not only mesenchymal tissues (bone, cartilage) but also many other kinds of tissues, including heart, skin, and liver. Autologous BMSCs are thought to be safe because of the absence of immunological reaction and disease transmission. However, it is possible that they will form tumours during long-term follow-up. In 1988, we transplanted autologous BMSCs to repair articular cartilage, which was the first such trial ever reported. Subsequently we performed this procedure in about 40 patients. Demonstration that neither partial infections nor tumours appeared in these patients provided strong evidence for the safety of autologous BMSC transplantation. Thus, in this study we checked these patients for tumour development and infections. Between January 1998 and November 2008, 41 patients received 45 transplantations. We checked their records until their last visit. We telephoned or mailed the patients who had not visited the clinics recently to establish whether there were any abnormalities in the operated joints. Neither tumours nor infections were observed between 5 and 137 (mean 75) months of follow-up. Autologous BMSC transplantation is a safe procedure and will be widely used around the world. Copyright (C) 2010 John Wiley & Sons, Ltd.