Cancer metabolism in space and time: Beyond the Warburg effect
Cancer metabolism in space and time: Beyond the Warburg effect
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DOI：
10.1016/j.bbabio.2017.02.001
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发表时间：
2017-08-01
影响因子：
4.3
通讯作者：
Porporato, Paolo E.
中科院分区：
文献类型：
--
作者：
Danhier, Pierre;Banski, Piotr;Porporato, Paolo E.
癌细胞中代谢的改变对肿瘤生长至关重要，最显著的是通过提供能量、减少当量和构建模块，而几种代谢物发挥促进肿瘤生长和进展的信号传导功能。癌组织不能简单地减少到大量的增殖细胞。肿瘤确实是复杂和动态的结构，其中单个细胞可以不均匀地执行具有不同代谢要求的各种生物活性。由于肿瘤由不同类型的细胞组成，其代谢活动受到不同空间和时间背景的影响，因此考虑到细胞和生物异质性来解决代谢问题是很重要的。在这篇综述中，我们描述了这种异质性也在代谢通量，从而显示不同的代谢活动的相对贡献肿瘤进展根据细胞的情况。这篇文章是由Giuseppe Gasparre，Rodrigue Rossignol和Pierre Sonveaux编辑的题为癌症中的线粒体的特刊的一部分。(C)2017爱思唯尔B.V.保留所有权利。
Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing energy, reducing equivalents and building blocks while several metabolites exert a signaling function promoting tumor growth and progression. A cancer tissue cannot be simply reduced to a bulk of proliferating cells. Tumors are indeed complex and dynamic structures where single cells can heterogeneously perform various biological activities with different metabolic requirements. Because tumors are composed of different types of cells with metabolic activities affected by different spatial and temporal contexts, it is important to address metabolism taking into account cellular and biological heterogeneity. In this review, we describe this heterogeneity also in metabolic fluxes, thus showing the relative contribution of different metabolic activities to tumor progression according to the cellular context. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux. (C) 2017 Elsevier B.V. All rights reserved.