Deleterious mutations in animal mitochondrial DNA
Deleterious mutations in animal mitochondrial DNA
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DOI：
10.1023/a:1017030708374
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发表时间：
1998-01-01
期刊：
影响因子：
1.5
通讯作者：
Nachman, MW
中科院分区：
文献类型：
--
作者：
Nachman, MW
一个简单的中性模型预测，物种之间的非同义固定差异与同义固定差异的比率将与物种内的非同义多态性与同义多态性的比率相同。这一预测与现有的线粒体数据集从25个动物物种进行了测试。在略多于一半的研究中，物种内替换与沉默多态性的比率显著大于物种间替换与沉默固定差异的比率。这些观察结果最好的解释是大量的轻度有害的氨基酸突变，有助于杂合性，但很少成为固定的。
A simple neutral model predicts that the ratio of non-synonymous to synonymous fixed differences between species will be the same as the ratio of non-synonymous to synonymous polymorphisms within species. This prediction is tested with existing mitochondrial datasets from 25 animal species. In slightly over half of the studies, the ratio of replacement to silent polymorphisms within species is significantly greater than the ratio of replacement to silent fixed differences between species. These observations are best explained by a substantial number of mildly deleterious amino acid mutations that contribute to heterozygosity but rarely become fixed.