A new method for dissolution testing of vitamin E preparations in test medium containing sodium glycochenodeoxycholate.
A new method for dissolution testing of vitamin E preparations in test medium containing sodium glycochenodeoxycholate.
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维生素 E 制剂在含有甘氨鹅脱氧胆酸钠的测试介质中溶出度测试的新方法。
DOI：
10.1248/cpb.34.2196
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发表时间：
1986
影响因子：
1.7
通讯作者：
T. Nagai
中科院分区：
文献类型：
--
作者：
Y. Tsushima;S. Yamagiwa;K. Tatsuishi;M. Kayano;T. Tokumura;Y. Machida;T. Nagai
建立了油溶性和水溶性药物制剂溶出度测定方法。结果表明，以d-α-生育酚为模型药物的制剂可采用桨叶法在JP X和含20mM糖鹅脱氧胆酸钠的JP X中进行溶出试验。该方法获得的数据可用于预测药物的体内吸收。而含d-α-生育酚的胶囊在棉籽油中溶解时，药物和载药体浮在溶出试验介质表面，未见良好的溶出。
A method for dissolution testing of oily and water-isoluble drug preparations was developed.It was found that dissolution testing of a preparation containing d-α-tocopherol as a model drug could be done by using the paddle method in JP X and the 2nd fluid in JP X containing 20mM sodium glycochenodeoxycholate. The data obtaiend by the methdo were useful for predicting in vivo absorption of the drug. However, in the case of a capsule containing d-α-tocopherol dissolved in cottonseed oil, the drug and vehicle floated on the surface of the disslution test medium, and good dissolution was not observed.