Plasma miR-145 as a novel biomarker for the diagnosis and radiosensitivity prediction of human cervical cancer.
Plasma miR-145 as a novel biomarker for the diagnosis and radiosensitivity prediction of human cervical cancer.
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DOI：
10.1177/0300060517709614
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Jun-Bo J
中科院分区：
文献类型：
--
作者：
Wei H;Wen-Ming C;Jun-Bo J
本研究的目的是评估宫颈癌（CC）患者血浆miR-145的水平，并研究其生物标志物的潜力。使用qRT-PCR，我们比较了120例CC患者、120例宫颈上皮内瘤变（CIN）患者和120例健康志愿者的血浆miR-145水平。还分析了血浆miR-145表达与临床病理因素（包括放射反应）之间的相关性。CC患者的血浆miR-145水平低于CIN患者和健康对照。低水平与癌症分化差、淋巴结转移、HPV和晚期FIGO分期显著相关。对放疗达到完全应答的CC患者的血浆miR-145水平高于不完全应答者。ROC分析证实，血浆miR-145是检测CC和区分完全应答者与不完全应答者的候选生物标志物。血浆miR-145在CC中减少，是诊断CC和预测放射敏感性的新的候选生物标志物。
The objective of this study was to evaluate levels of plasma miR-145 in patients with cervical cancer (CC) and investigate its biomarker potential. Using qRT-PCR, we compared plasma miR-145 levels in 120 patients with CC, 120 patients with cervical intraepithelial neoplasia (CIN), and 120 healthy volunteers. The association between plasma miR-145 expression and clinicopathological factors, including radiation response, was also analyzed. Plasma miR-145 levels were lower in CC patient than in CIN patients and healthy controls. Low levels were significantly associated with poor cancer differentiation, lymph node metastasis, HPV, and advanced FIGO stage. CC patients who achieved complete response to radiotherapy had higher plasma miR-145 levels than incomplete responders. ROC analysis confirmed that plasma miR-145 is a candidate biomarker for detecting CC and differentiating complete responders from incomplete responders. Plasma miR-145 is reduced in CC and is a novel candidate biomarker for diagnosing CC and predicting radiosensitivity.
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作者：
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通讯作者：
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发表时间：
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