The Study of Muscle, Mobility and Aging (SOMMA). A Unique Cohort Study about the Cellular Biology of Aging and Age-related Loss of Mobility.

The Study of Muscle, Mobility and Aging (SOMMA). A Unique Cohort Study about the Cellular Biology of Aging and Age-related Loss of Mobility.
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肌肉、活动能力和衰老研究 (SOMMA)。

DOI：
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发表时间：
2023
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
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通讯作者：
P. Cawthon
P. Cawthon
中科院分区：
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文献类型：
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作者：
Steve Cummings;A. Newman;Paul M Coen;R. Hepple;Robin Collins;Kimberly Kennedy;M. Danielson;K. Peters;T. Blackwell;Eileen Johnson;T. Mau;E. Shankland;L. Lui;Sheena M Patel;Danielle Young;N. Glynn;E. Strotmeyer;K. Esser;D. Marcinek;B. Goodpaster;S. Kritchevsky;P. Cawthon

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背景
BACKGROUND The Study of Muscle, Mobility and Aging (SOMMA) aims to understand the biological basis of many facets of human aging, with a focus on mobility decline, by creating a unique platform of data, tissues, and images. METHODS The multidisciplinary SOMMA team includes two clinical centers (University of Pittsburgh and Wake Forest University), a biorepository (Translational Research Institute at Advent Health), and the San Francisco Coordinating Center (California Pacific Medical Center Research Institute). Enrollees were age ≥70 years, able to walk ≥0.6 m/s (4 meters); able to complete 400m walk, free of life-threatening disease, and had no contraindications to magnetic resonance or tissue collection. Participants are followed with 6-month phone contacts and annual in-person exams. At baseline, SOMMA collected biospecimens (muscle and adipose tissue, blood, urine, fecal samples); a variety of questionnaires; physical and cognitive assessments; whole-body imaging (magnetic resonance and computed tomography); accelerometry; and cardiopulmonary exercise testing. Primary outcomes include change in walking speed, change in fitness, and objective mobility disability (able to walk 400m in 15 min and change in 400m speed). Incident events, including hospitalizations, cancer diagnoses, fractures, and mortality are collected and centrally adjudicated by study physicians. RESULTS SOMMA exceeded its goals by enrolling 879 participants, despite being slowed by the COVID-19 pandemic: 59.2% women; mean age 76.3±5.0 years (range 70-94); mean walking speed 1.04±0.20 m/s; 15.8% identify as other than Non-Hispanic White. Over 97% had data for key measurements. CONCLUSIONS SOMMA will provide the foundation for discoveries in the biology of human aging and mobility.