MMP-2 expression in 102 patients with glottic laryngeal cancer
MMP-2 expression in 102 patients with glottic laryngeal cancer
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DOI：
10.1007/s00405-011-1625-8
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发表时间：
2012-02-01
影响因子：
2.6
通讯作者：
Papadas, Theodoros A.
中科院分区：
文献类型：
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作者：
Mallis, Antony;Teymoortash, Afshin;Papadas, Theodoros A.
目的探讨基质金属蛋白酶2(MMP2)作为声门型喉癌预后指标的可能性。对1998年至2005年在希腊帕特拉斯大学医院接受喉切除术的102例声门型喉癌患者的手术标本进行了回顾性研究，以检测基质金属蛋白酶-2的表达。免疫组织化学染色采用链霉亲和素-生物素过氧化物酶复合法(LSAB)。结果显示，102例患者中有54例(52.9%)胞浆表达MMP2。经Kaplan-Meier分析，MMP2阳性组与阴性组的5年总生存率差异有统计学意义(p=0.037)，无瘤生存率差异有统计学意义(p=0.048)。转移性淋巴结包膜破裂与原发灶MMP2的表达似乎也有相关性(p=0.047)。MMP2的表达与肿瘤的临床病理特征(T分期、N分期、临床分期、分化程度)之间无统计学意义。综上所述，基质金属蛋白酶-2的表达与总生存率和无瘤生存率有关，可作为预后不良的潜在标志。
In order to evaluate the potential of matrix metalloproteinase 2 (MMP-2) as a prognostic factor for glottic laryngeal cancer. One hundred and two surgical specimens from patients with glottic laryngeal cancer who underwent laryngectomy for their disease in the University Hospital of Patras, Greece from 1998 to 2005 were reviewed retrospectively regarding MMP-2 expression via immunohistochemistry. Immunostaining was performed using a streptavidin-biotin peroxidase complex technique (LSAB). Results revealed that 54 of 102 patients (52.9%) had positive cytoplasmic staining for MMP-2. Kaplan-Meier analysis demonstrated statistically significant difference (p = 0.037) for the 5-year overall survival rate between the groups with positive and negative MMP-2 expression, and marginal statistical significance for the disease free survival rate (p = 0.048). The capsule rupture of metastatic lymph nodes and MMP-2 expression in primary tumor site also seems to be related (p = 0.047). Statistical significance could not be established between MMP-2 expression and the clinicopathological features of the disease (T stage, N stage, clinical stage, differentiation). In conclusion, MMP-2 expression was related with worse overall and disease-free survival and could be considered as a potential marker of poor prognosis.