NEW CYCLIC-PEPTIDES WITH CYTO-TOXIC ACTIVITY FROM THE ASCIDIAN LISSOCLINUM-PATELLA
NEW CYCLIC-PEPTIDES WITH CYTO-TOXIC ACTIVITY FROM THE ASCIDIAN LISSOCLINUM-PATELLA
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DOI：
10.1021/jm00126a034
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发表时间：
1989-06-01
影响因子：
7.3
通讯作者：
WATTERS, DJ
中科院分区：
文献类型：
--
作者：
DEGNAN, BM;HAWKINS, CJ;WATTERS, DJ
本文报道了从海鞘中分离得到的1个新的甲基苯丙酰胺(D)和2个新的利索克林胺(4和5)的结构。结构主要通过二维核磁共振技术和质谱学确定。这些多肽以及之前报道的帕特莱胺和利索克林胺家族的其他成员都是在扑氯隆属的专性藻类共生体中发现的。报道了这些化合物对成纤维细胞和肿瘤细胞的细胞毒性。其中一种化合物，利索克林胺4，明显比该家族的其他成员毒性更大。讨论了构效关系。
The isolation and structures of a new patellamide (patellamide D) and two new lissoclinamides (lissoclinamides 4 and 5) from the aplousobranch ascidian Lissoclinum patella are described. Structures were determined largely by using two-dimensional NMR techniques and mass spectrometry. These peptides and other members of the patellamide and lissoclinamide families that have been reported previously are found within the obligate algal symbiont of the genus Prochloron. The cytotoxicities of the compounds toward fibroblast and tumor cell lines are reported. One of these compounds, lissoclinamide 4, is markedly more toxic than other members of the family. Structure-activity relationships are discussed.