Neurologic complications of COVID-19.
Neurologic complications of COVID-19.
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DOI：
10.1016/j.ajem.2020.05.024
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发表时间：
2020-07-01
期刊：
影响因子：
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通讯作者：
Gottlieb, Michael
中科院分区：
文献类型：
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作者：
Bridwell, Rachel;Long, Brit;Gottlieb, Michael
背景技术背景：关于2019年冠状病毒病（COVID-19）全球大流行的大部分焦点都集中在心血管、肺部和血液系统并发症上。然而，神经系统并发症已经成为一个越来越被认可的发病率和死亡率领域。目的：这份简短的报告总结了与COVID-19相关的神经系统并发症，重点是急诊医学临床医生。虽然肺部并发症严重，但神经系统也受到显著影响，并发症包括急性脑血管事件、脑炎、格林-巴利综合征、急性坏死性出血性脑病和噬血细胞性淋巴组织细胞增多症。此外，因既存神经系统问题而接受免疫抑制药物治疗的患者发生COVID-19感染并发症的风险增加，目前提出的许多COVID-19治疗方法可能与这些药物相互作用。结论：在护理COVID-19患者时，急诊医学临床医生应了解COVID-19的神经系统并发症。
BACKGROUND: Much of the focus regarding the global pandemic of coronavirus disease of 2019 (COVID-19) has been on the cardiovascular, pulmonary, and hematologic complications. However, neurologic complications have arisen as an increasingly recognized area of morbidity and mortality.OBJECTIVE: This brief report summarizes the neurologic complications associated with COVID-19 with an emphasis on the emergency medicine clinician.DISCUSSION: COVID-19 has infected over 3.5 million people and killed over 240,000 people worldwide. While pulmonary complications are profound, the neurologic system is also significantly impacted, with complications including acute cerebrovascular events, encephalitis, Guillain-Barre syndrome, acute necrotizing hemorrhagic encephalopathy, and hemophagocytic lymphohistiocytosis. Additionally, patients on immunosuppressive medications for pre-existing neurologic issues are at an increased risk for complications with COVID-19 infection, and many of the currently proposed COVID-19 therapies can interact with these medications.CONCLUSIONS: When caring for COVID-19 patients, emergency medicine clinicians should be aware of the neurologic complications from COVID-19.