Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study.
Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study.
复制标题
氧甾醇与老年人轻度认知障碍之间的关系：病例对照研究
DOI：
10.1186/s12944-016-0344-y
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发表时间：
2016-10-10
影响因子：
4.5
通讯作者：
Xiao R
中科院分区：
文献类型：
--
作者：
Liu Q;An Y;Yu H;Lu Y;Feng L;Wang C;Xiao R
在一项匹配的病例对照研究中探究氧甾醇与轻度认知障碍（MCI）之间的关系。
采用高效液相色谱 - 质谱法（HPLC - MS）分析四种氧甾醇，即27 - 羟基胆固醇（27 - OHC）、24S - 羟基胆固醇（24S - OHC）、7α - 羟基胆固醇（7α - OHC）和7β - 羟基胆固醇（7β - OHC）的血浆水平，并在70例MCI患者和140例认知正常的匹配对照者之间进行比较。使用逻辑回归分析计算比值比（OR）以评估氧甾醇与MCI之间的关联。
与认知正常的对照者相比，MCI患者的27 - OHC血浆水平显著更高。逻辑回归分析表明，即使在多变量调整后，高血浆水平的27 - OHC仍与MCI显著相关（OR = 2.86，95%置信区间：1.52 ~ 5.37）。
我们的研究结果表明，27 - OHC血浆水平升高与MCI相关，提示高血浆水平的27 - OHC可能在MCI的发展中起重要作用。
To investigate the relationship between oxysterols and mild cognitive impairment (MCI) in a matched case–control study. The plasma levels of four oxysterols, 27–hydroxycholesterol (27–OHC), 24S–hydroxycholesterol (24S–OHC), 7α–hydroxycholesterol (7α–OHC) and 7β–hydroxycholesterol (7β–OHC), were analyzed by High Performance Liquid Chromatography–Mass Spectrometry (HPLC–MS) and compared between 70 MCI patients and 140 matched controls with normal cognition. The odds ratio (OR) was calculated using logistic analyses to assess the association between oxysterols and MCI. Compared with controls with normal cognition, plasma level of 27–OHC was significantly higher in MCI patients. Logistic analyses suggested high plasma level of 27–OHC was significantly associated with MCI even after multivariate adjustment (OR = 2.86, 95 % CI: 1.52 ~ 5.37). Our findings suggested that the increased plasma level of 27-OHC was associated with MCI, suggesting high plasma levels of 27-OHC may pay an important role in the development of MCI.
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DOI：
10.3233/jad-2012-111460
发表时间：
2012
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Hughes TM;Kuller LH;Lopez OL;Becker JT;Evans RW;Sutton-Tyrrell K;Rosano C
通讯作者：
Rosano C
影响因子：
3.6
作者：
Li X;Song D;Leng SX
通讯作者：
Leng SX
影响因子：
9.9
作者：
Pappolla, MA;Bryant-Thomas, TK;Refolo, LM
通讯作者：
Refolo, LM
影响因子：
105.7
作者：
Kivipelto, M;Helkala, EL;Nissien, A
通讯作者：
Nissien, A
脑胆固醇代谢，氧甲醇和痴呆。
DOI：
10.3233/jad-2012-121585
发表时间：
2013
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Hughes TM;Rosano C;Evans RW;Kuller LH
通讯作者：
Kuller LH