Antimelanogenic Activity of Ocotillol-Type Ginsenosides from Panax vietnamensis Ginseng
Antimelanogenic Activity of Ocotillol-Type Ginsenosides from Panax vietnamensis Ginseng
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DOI：
10.1002/cbdv.202000037
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发表时间：
2020-04-15
影响因子：
2.9
通讯作者：
Morita, Hiroyuki
中科院分区：
文献类型：
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作者：
Hien Minh Nguyen;Huy Truong Nguyen;Morita, Hiroyuki
ocotillol（OCT）型皂苷已知为四环三萜类化合物，在侧链中具有五元或六元环氧环。有趣的是，这种类型的皂苷主要存在于越南参中，五加科（VG），因此使VG独特的其他人参属。评价了五种OCT型皂苷（majonoside R2、vina-pyruvate R2、majonoside R1、pseudo-pyruvate RT 4、vina-pyruvate R11）以及三种原人参二醇（PPD）型皂苷和四种原人参三醇（PPT）型皂苷的抗黑色素生成活性。所有分离物均具有活性。更重要的是，五种OCT型皂苷抑制B16-F10小鼠黑色素瘤细胞中的黑色素产生，而没有显示出任何细胞毒性。除了PPD中的β-Rd和β-Rg 3以及PPT型皂苷中的三七皂苷R1外，majonoside R2是OCT型皂苷中最强的黑素生成抑制活性。本文重点介绍了OCT型皂苷的抗黑色素生成活性及其潜在的构效关系。我们的研究结果表明，OCT型皂苷可用作脱色剂。
The ocotillol (OCT)-type saponins have been known as a tetracyclic triterpenoid, possessing five- or six-membered epoxy ring in the side chain. Interestingly, this type saponin was mostly found in Panax vietnamensis Ha et Grushv., Araliaceae (VG), hence making VG unique from the other Panax spp. Five OCT-type saponins, majonoside R2, vina-ginsenoside R2, majonoside R1, pseudoginsenoside RT4, vina-ginsenoside R11, together with three protopanaxadiol (PPD)-type saponins and four protopanaxatriol (PPT)-type saponins from VG were evaluated for their antimelanogenic activity. All of isolates were found to be active. More importantly, the five OCT-type saponins inhibited melanin production in B16-F10 mouse melanoma cells, without showing any cytotoxicity. Besides ginsenoside Rd and ginsenoside Rg3 in PPD and notoginsenoside R1 in PPT-type saponins, majonoside R2 was the most potent melanogenesis inhibitory activity in OCT-type saponins. In this article, we highlighted antimelanogenic activity of OCT-type saponins and potential structure-activity relationship (SAR) of ginsenosides. Our results suggested that OCT-type saponins could be used as a depigmentation agent.