Multiple false reactions in viral antibody screening assays after influenza vaccination.
Multiple false reactions in viral antibody screening assays after influenza vaccination.
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流感疫苗接种后病毒抗体筛查测定中出现多种错误反应。
DOI：
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发表时间：
1995
影响因子：
5
通讯作者：
L. Schonberger
中科院分区：
文献类型：
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作者：
L. Simonsen;J. Buffington;C. Shapiro;R. Holman;T. Strine;B. Grossman;A. Williams;L. Schonberger
1991年12月，美国血液中心报告，对以下两种或两种以上病毒(人类免疫缺陷病毒1型(HIV-1)、人类T细胞淋巴营养病毒I型(HTLV-I)和丙型肝炎病毒)的抗体检测为假反应的捐赠量出现了异常增长。这些捐赠中的许多来自最近接种了1991-1992年流感疫苗的人，这增加了这种疫苗不知何故特定地导致了多重假反应问题的可能性。对101名受影响的捐赠者和191名匹配的对照进行的病例对照研究发现，最近接受任何品牌的流感疫苗接种与多重假阳性(P<；0.05)显著相关，最近急性疾病史(P<；0.05)和过敏史(P<；0.05)也是如此。1990年5月至1992年12月期间对多重反应捐赠月率的监测将多重假阳性捐赠的季节性群组与使用被认为对捐赠者免疫球蛋白M产生非特异性反应的病毒筛选试剂盒的使用联系起来。在更换艾滋病毒-1和丙型肝炎病毒检测后的1992-1993年流感疫苗接种季节期间，多次假阳性捐赠没有类似的增加；然而，仅对HTLV-I型假反应的捐赠数量几乎翻了一番，表明假反应与1991-1992年的流感疫苗无关。对受影响的捐献者重新检测发现，HTLV-I和丙型肝炎病毒假反应的持续时间为3-6个月。1991年出现的多次假阳性捐赠很可能是由使用的检测试剂盒造成的，而不是由流感疫苗造成的。
In December 1991, US blood centers reported an unusual increase in donations that tested falsely reactive for antibodies to two or more (multiple false positive) of the following viruses: human immunodeficiency virus type 1 (HIV-1), human T-cell lymphotrophic virus type I (HTLV-I), and hepatitis C virus. Many of these donations were from people who had recently received the 1991-1992 influenza vaccine, raising the possibility that this vaccine had somehow specifically caused the problem of multiple false reactivity. A case-control study of 101 affected donors and 191 matched controls found that recent receipt of any brand of influenza vaccine was significantly associated with testing multiple false positive (p < 0.05), as was a history of recent acute illness (p < 0.05) and of allergies (p < 0.05). Surveillance for monthly rates of multiple reactive donations from May 1990 through December 1992 linked the seasonal cluster of multiple false-positive donations to the use of viral screening test kits thought to react nonspecifically to donor immunoglobulin M. There was no similar increase in multiple false-positive donations during the 1992-1993 influenza vaccination season after the HIV-1 and hepatitis C virus tests were replaced; however, the number of donations that were falsely reactive for only HTLV-I almost doubled, indicating that false reactivity was not specifically associated with the 1991-1992 influenza vaccine. Retesting of affected donors found that the duration of HTLV-I and hepatitis C virus false reactivity was 3-6 months. The cluster of multiple false-positive donations in 1991 was most likely caused by the test kits used, rather than by the influenza vaccine.