Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging
Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging
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DOI：
10.1364/oe.20.008726
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发表时间：
2012-04-09
期刊：
影响因子：
3.8
通讯作者：
Jiang, Huabei
中科院分区：
文献类型：
--
作者：
Xi, Lei;Grobmyer, Stephen R.;Jiang, Huabei
利用光声效应在生物组织中进行生物医学成像是一种很有前途的方法。光声断层成像(PAT)因其丰富的光学对比度和单一成像方式的高分辨率，已被证明可用于乳腺癌、脑血管系统、关节炎和癫痫灶的成像。在这里，我们报告了一种基于微电子机械系统(MEMS)的术中PAT(IPAT)技术，并在荷瘤小鼠模型上展示了它能够准确地绘制三维肿瘤地图，并在手术中检查肿瘤切除的完整性。MEMS成像探头体积小，有可能方便地用于指导乳腺肿瘤的手术切除。(C)2012年美国光学学会
The use of photoacoustic effect is a promising approach for biomedical imaging in living tissues. Photoacoustic tomography (PAT) has been demonstrated to image breast cancer, brain vasculature, arthritis and seizure focus owing to its rich optical contrast and high resolution in a single imaging modality. Here we report a microelectromechanical systems (MEMS)-based intraoperative PAT (iPAT) technique, and demonstrate its ability to accurately map tumors in three-dimension and to inspect the completeness of tumor resection during surgery in a tumor-bearing mouse model. The MEMS imaging probe is small and has the potential to be conveniently used to guide surgical resection of tumors in the breast. (C) 2012 Optical Society of America