Socially related fears following exposure to trauma: Environmental and genetic influences

Socially related fears following exposure to trauma: Environmental and genetic influences
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DOI:
10.1016/j.janxdis.2008.07.006
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发表时间:
2009-03-01
影响因子:
10.3
通讯作者:
Jang, Kerry L.
Jang, Kerry L.
中科院分区:
医学2区
文献类型:
--
作者:
Collimore, Kelsey C.;Asmundson, Gordon J. G.;Jang, Kerry L.

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很少有研究探讨为什么社会相关的恐惧和创伤后压力通常,但并非总是同时发生。这可能是唯一的创伤人类机构(例如,性攻击),其中有人际关系的组成部分,引起同时发生的与社会有关的恐惧。这些症状也可能由于共同的遗传因素而共同发生。我们调查了882例同卵双胞胎和异卵双胞胎的样本。与社会相关的恐惧没有显著差异(即,对负面评价的恐惧,对社会上可观察到的唤醒症状的恐惧)在报告攻击性或非攻击性创伤的参与者之间发现。然而,当参与者被分为可能的PTSD和无PTSD组时,发现与社会相关的恐惧存在显着差异。可能患有PTSD的参与者表现出更大的社会相关恐惧(即,害怕负面评价)比没有创伤后应激障碍的人要多。使用生物统计结构方程模型,创伤暴露最好的解释共享和非共享的环境影响。对社会上可观察到的唤醒症状的恐惧受到遗传和非共享环境影响的影响。对未来研究的意义和方向进行了讨论。(C)2008爱思唯尔有限公司保留所有权利。
Few studies have examined why socially related fears and posttraumatic stress commonly, but not invariably, co-occur. It may be that only traumata of human agency (e.g., sexual assault), for which there is an interpersonal component, give rise to co-occurring socially related fears. These symptoms might also co-occur because of shared genetic factors. We investigated these issues using a sample of 882 monozygotic and dizygotic twins. No significant differences in socially related fear (i.e., fear of negative evaluation, fear of socially observable arousal symptoms) were found between participants reporting assaultive or nonassaultive trauma. However, significant differences in socially related fear were found when participants were grouped into probable PTSD and no PTSD groups. Participants with probable PTSD exhibited greater socially related fear (i.e., fear of negative evaluation) than those without PTSD. Using biometric structural equation modeling, trauma exposure was best explained by shared and nonshared environmental influences. The fear of socially observable arousal symptoms was influenced by genetic and nonshared environmental influences. Implications and directions for future research are discussed. (C) 2008 Elsevier Ltd. All rights reserved.