The Determination of Rod and Cone Photoreceptor Fate
The Determination of Rod and Cone Photoreceptor Fate
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DOI：
10.1146/annurev-vision-090814-121657
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Cepko, Constance L.
中科院分区：
文献类型：
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作者：
Cepko, Constance L.
光感受器是研究最深入的视网膜细胞类型。早期谱系研究表明，光感受器由仅产生光感受器细胞的视网膜祖细胞（RPC）和产生光感受器细胞和其他视网膜细胞类型的RPC产生。最近的谱系研究表明，这些RPC之间存在内在的分子差异，这些分子差异在基因调控网络（GRNs）中起作用，导致视杆细胞与视锥细胞命运的选择。此外，还有GRN导致选择感光细胞的命运和另一种视网膜细胞类型。这种GRN的一个例子是驱动视杆细胞和双极细胞之间的二元命运选择的GRN。这个GRN有许多元素，包括前馈和反馈调节回路，突出了这种网络的复杂性。视网膜细胞命运决定的这一点和其他例子在这里进行审查，集中在直接的视杆细胞和视锥细胞的命运的选择的事件。
Photoreceptors have been the most intensively studied retinal cell type. Early lineage studies showed that photoreceptors are produced by retinal progenitor cells (RPCs) that produce only photoreceptor cells and by RPCs that produce both photoreceptor cells and other retinal cell types. More recent lineage studies have shown that there are intrinsic, molecular differences among these RPCs and that these molecular differences operate in gene regulatory networks (GRNs) that lead to the choice of the rod versus the cone fate. In addition, there are GRNs that lead to the choice of a photoreceptor fate and that of another retinal cell type. An example of such a GRN is one that drives the binary fate choice between a rod photoreceptor and bipolar cell. This GRN has many elements, including both feedforward and feedback regulatory loops, highlighting the complexity of such networks. This and other examples of retinal cell fate determination are reviewed here, focusing on the events that direct the choice of rod and cone photoreceptor fate.