Cell-free DNA levels in acute myocardial infarction patients during hospitalization
Cell-free DNA levels in acute myocardial infarction patients during hospitalization
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DOI：
10.2143/ac.64.1.2034362
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发表时间：
2009-02-01
影响因子：
1.6
通讯作者：
Kanavakis, Emmanouel
中科院分区：
文献类型：
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作者：
Destouni, Aspasia;Vrettou, Christina;Kanavakis, Emmanouel
目的：研究急性心肌梗死(AMI)患者入院后日内游离DNA浓度的变化及其与住院期间并发症的相关性。方法与结果：采用实时定量聚合酶链式反应技术检测了47例急性心肌梗死患者住院期间(235例)和100例健康体检者的血清游离DNA水平。患者在整个住院期间的游离DNA浓度显著高于健康受试者水平(2.644(SE 0.0952)比1.519(SE 0.0566)，P
Objectives - The objectives of this study were to investigate cell-free DNA daily concentration changes following an acute myocardial infarction (AMI) and to assess any correlations with complications during hospitalization.Methods and results - Serial cell-free DNA level determinations were performed by quantitative Real-Time PCR in 47 AMI patients once daily during hospitalization (235 samples) and once in 100 healthy subjects. Cell-free DNA concentrations are significantly higher in patients throughout hospitalization compared to healthy subject levels (2.644 (SE 0.0952) vs. 1.519 (SE 0.0566), P