Metabolism and Alzheimer’s Disease
Metabolism and Alzheimer’s Disease
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新陈代谢和阿尔茨海默病
DOI：
10.1007/978-1-59259-661-4_4
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发表时间：
2004
期刊：
影响因子：
3.5
通讯作者：
J. Blass
中科院分区：
文献类型：
--
作者：
J. Blass
阿尔茨海默病（AD）患者的大脑中有许多异常，特别是在尸检中获得的组织中。AD患者通常在疾病的晚期死亡，尽管有时其他疾病或事故导致早期AD死亡。尸检脑内的异常可能是濒死和死后伪影的结果。因此，一个主要的问题是试图确定AD脑中的哪些异常是原发性的，哪些是继发于疾病或终末状态的。
Many abnormalities have been described in the brains of patients with Alzheimer’s disease (AD), particularly in tissue obtained at autopsy. AD patients usually die in late stages of the disease, although sometimes other illnesses or accidents lead to death in early AD. Abnormalities in autopsy brain can be the result of agonal and postmortem artifacts. A major issue has therefore been to try to decide which abnormalities in AD brain are primary and which are secondary to the disease or to the terminal state.