The Characteristics and Patterns of Drug-Resistant Pulmonary Tuberculosis in Eastern India.
The Characteristics and Patterns of Drug-Resistant Pulmonary Tuberculosis in Eastern India.
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DOI：
10.3390/tropicalmed7090244
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发表时间：
2022-09-13
影响因子：
2.9
通讯作者：
Kanodia S
中科院分区：
文献类型：
--
作者：
Giri VP;Giri OP;Pandey PT;Mishra KN;Prasad RS;Lal PK;Pratap R;Nikhil N;Sufian A;Ahmad R;Kanodia S
背景：耐药结核病是世界各地的一个主要公共卫生问题，在印度也造成了很高的发病率和死亡率。早期诊断是结核病治疗的基石。国家层面和群体层面的耐药性变化是可能存在的，应不时定期检查。材料与方法：本前瞻性队列研究（2019年1月至2022年5月）在达尔班加医学院医院对耐药肺结核患者进行研究。痰标本从指定的中心采集。快速分子耐药试验（基因型试验）和基于生长的药敏试验（表型试验）在国家消除结核病规划认证的实验室进行。结果：共纳入268例耐药肺结核患者。治愈100例（37.31%）；完成治疗43例（16.04%）；死亡56例（20.89%）；治疗失败22例（8.21%）；随访失败34例（12.69%）；转移出耐药肺结核13例（4.85%）。199例耐药肺结核患者出现不良事件，占74.25%。结论：耐药肺结核患者是一个值得关注和重视的问题。
Background: Drug-resistant tuberculosis is a major public health problem throughout the world and accounts for substantial morbidity and mortality rates in India, too. Early diagnosis is the corner stone of tuberculosis treatment. State-level and cluster-wise variations in drug resistance is a possibility and should be regularly checked in from time to time. Materials and Methods: The present prospective cohort study (January 2019 to May 2022) was conducted in Darbhanga Medical College and Hospital on drug-resistant pulmonary tuberculosis patients. Sputum specimens were collected from designated centers. Rapid molecular drug-resistance testing (genotypic tests) and growth-based drug-susceptibility testing (DST) (phenotypic tests) were performed in the National Tuberculosis Elimination Program certified Laboratory. Results: A total of 268 patients with drug-resistant pulmonary tuberculosis were included in the study group. The treatment outcomes revealed as cured in 100 (37.31%); treatment completed in 43 (16.04%); died in 56 (20.89%); treatment failed in 22 (8.21%); loss of follow up in 34 (12.69%); and transferred out in 13 (4.85%) drug-resistant pulmonary tuberculosis patients. Adverse events were recorded in 199 (74.25%) of the drug-resistant pulmonary tuberculosis patients. Conclusions: Drug-resistant pulmonary tuberculosis patients are a matter of concern and need to be addressed.
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影响因子：
56.3
作者：
Ndjeka, Norbert;Campbell, Jonathon R.;Meintjes, Graeme;Maartens, Gary;Schaaf, H. Simon;Hughes, Jennifer;Padanilam, Xavier;Reuter, Anja;Romero, Rodolfo;Ismail, Farzana;Enwerem, Martin;Ferreira, Hannetjie;Conradie, Francesca;Naidoo, Kogieleum;Menzies, Dick
通讯作者：
Menzies, Dick
影响因子：
24.3
作者：
Borisov, Sergey E.;Dheda, Keertan;Migliori, Giovanni Battista
通讯作者：
Migliori, Giovanni Battista
DOI：
10.1515/jbcpp-2020-0468
发表时间：
2021-07-01
影响因子：
--
作者：
Pratama, Novan Yusuf Indra;Zulkarnain, Bambang Subakti;Fatmawati, Umi
通讯作者：
Fatmawati, Umi
影响因子：
2.9
作者：
Putra ON;Hidayatullah AYN
通讯作者：
Hidayatullah AYN
影响因子：
76.2
作者：
Schnippel, Kathryn;Ndjeka, Norbert;Conradie, Francesca
通讯作者：
Conradie, Francesca