In Vitro Activity of Netilmicin Compared with Gentamicin, Tobramycin, Amikacin, and Kanamycin
In Vitro Activity of Netilmicin Compared with Gentamicin, Tobramycin, Amikacin, and Kanamycin
复制标题
奈替米星与庆大霉素、妥布霉素、阿米卡星和卡那霉素的体外活性比较
DOI：
10.1128/aac.11.5.791
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发表时间：
1977
影响因子：
4.9
通讯作者：
J. Ehret
中科院分区：
文献类型：
--
作者：
T. Eickhoff;J. Ehret
本文比较了奈替米星与庆大霉素、妥布霉素、阿米卡星和卡那霉素对临床分离的636株细菌的体外抗菌活性。庆大霉素是活性最高的抗生素，但奈替米星和妥布霉素与之相近，奈替米星对沙雷氏菌属和A组链球菌的活性通常比庆大霉素低4 - 8倍，对铜绿假单胞菌的活性低2倍。当评价培养基中接种量和二价阳离子浓度的影响时，奈替米星在体外与庆大霉素相似。在Mueller-Hinton肉汤中，当Mg 2+和Ca 2+浓度增加到生理水平时，铜绿假单胞菌的最小抑制浓度增加多达18倍。
The in vitro activity of netilmicin was compared with that of gentamicin, tobramycin, amikacin, and kanamycin against 636 strains of bacteria recently isolated from clinical sources. Gentamicin was the most active antibiotic, but netilmicin and tobramycin closely paralleled it. Netilmicin was generally four-to eightfold less active than gentamicin against Serratia and group A streptococci, and was twofold less active against Pseudomonas aeruginosa. When effects of inoculum size and concentration of divalent cations in the media were evaluated, netilmicin was shown to be similar to gentamicin in vitro. Minimum inhibitory concentrations for P. aeruginosa were increased as much as 18-fold when the Mg2+ and Ca2+ concentrations were increased to physiological levels in Mueller-Hinton broth.