Circulatory reflexes in chronic disease of the afferent nervous system
Circulatory reflexes in chronic disease of the afferent nervous system
复制标题
传入神经系统慢性疾病的循环反射
DOI：
10.1113/jphysiol.1956.sp005621
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发表时间：
1956
期刊：
影响因子：
--
通讯作者：
E. Sharpey
中科院分区：
文献类型：
--
作者：
E. Sharpey
Studies on the circulation would be simplified if it were possible to interrupt the afferent pathways of baroceptor reflexes in man. It would allow differentiation of reflex changes from those which are central or mechanical in origin, while work on problems such as water-salt retention, pressure-flow relationships in the periphery, and the maintenance of cardiac filling pressure would also be facilitated. It is not possible in man to denervate these receptors either by drugs or by surgery; but it will be shown in this paper that a relatively common disease, tabes dorsalis, is associated with apparent interruption of afferent baroceptor impulses. It has been found in normal subjects (Sharpey-Schafer, 1953, 1955, 1956) that an acute decrease in arterial pulse pressure causes reflex vasoconstriction and an acute increase, vasodilatation. Both these effects are mediated through the baroceptors. Vasodilatation also results from large imposed transients such as coughs. Similar methods have been used to study cases of tabes dorsalis.
