Hepatoprotective effects of whey protein on D-galactosamine-induced hepatitis and liver fibrosis in rats
Hepatoprotective effects of whey protein on D-galactosamine-induced hepatitis and liver fibrosis in rats
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DOI：
10.1271/bbb.70.1281
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发表时间：
2006-05-01
影响因子：
1.6
通讯作者：
Sasaki, Hajime
中科院分区：
文献类型：
--
作者：
Kume, Hisae;Okazaki, Keiko;Sasaki, Hajime
乳清蛋白对D-氨基半乳糖(300 mg/kg)两次注射的保肝作用。在以酪蛋白或乳清为蛋白质来源的改良AIN-93M饲料中喂养大鼠16天后，发现含有乳清蛋白的饲料明显抑制了血浆丙氨酸和天冬氨酸氨基转移酶活性、乳酸脱氢酶和胆红素(肝炎标志物)以及透明质酸(纤维化标志物)的增加。此外，它还抑制门脉纤维化、胆管增殖和静脉周围硬化的组织病理学征象。这些结果表明，补充乳清蛋白有助于预防肝炎和门脉纤维化的发展。
The hepatoprotective effects of whey protein on two injections Of D-galactosamine (300 mg/kg, i.p.) were investigated in rats fed a modified AIN-93M diet formulated with a protein source of casein or whey for 16 d. The whey protein-containing diet clearly suppressed an increase in plasma alanine and aspartate aminotransferase activity, lactate dehydrogenase and bilirubin, which are hepatitis markers, and also hyaluronic acid, a fibrosis marker. In addition, it suppressed histopathological signs of portal fibrosis, bile duct proliferation, and perivenular sclerosis. These results suggest that supplementation with whey protein can help prevent the development of hepatitis and portal fibrosis.