Representative Seroprevalences of Brucellosis in Humans and Livestock in Kyrgyzstan
Representative Seroprevalences of Brucellosis in Humans and Livestock in Kyrgyzstan
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DOI：
10.1007/s10393-011-0722-x
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发表时间：
2012-06-01
期刊：
影响因子：
2.5
通讯作者：
Schelling, Esther
中科院分区：
文献类型：
--
作者：
Bonfoh, Bassirou;Kasymbekov, Joldoshbek;Schelling, Esther
2007年，吉尔吉斯斯坦每10万人报告了77.5例新的人类布鲁氏菌病病例，这是世界上发病率最高的国家之一。在吉尔吉斯斯坦，目前在人类和动物身上使用的诊断试验是孟加拉玫瑰试验和哈德勒森试验。在人、牛、绵羊和山羊中进行了一项具有代表性的横断面研究，采用与大小成比例的整群抽样来评估人和动物的明显血清阳性率。共有4936份牲畜血清和1774份人类血清在纳林、丘伊和奥什Oblast进行了测试。布鲁氏菌病的总体表观血清流行率为人8.8%(95%CI 4.5~16.5)，牛2.8%(95%CI 1.6~4.9%)，绵羊3.3%(95%CI 1.5~6.9%)，山羊2.5%(95%CI 1.4~4.5%)。Naryn Oblast在人和羊中的血清抗体水平最高。血清阳性者男性多于女性(OR=1.96；P<；0.001)。人的血清阳性率与小型反刍动物的血清阳性率显著相关，而与牛的血清阳性率无明显关系。通过血清学测试，人类接触布鲁氏菌病的年发病率比报告的临床布鲁氏菌病病例的年发病率高出十倍以上。这表明人类布鲁氏菌病病例报告不足，即使只有一小部分血清阳性的人有临床症状。总之，这项研究证实了吉尔吉斯斯坦布鲁氏菌病的高血清阳性率，需要迅速有效的干预，包括对绵羊和山羊以及牛进行大规模疫苗接种。
Kyrgyzstan reported 77.5 new human brucellosis cases per 100,000 people in 2007, which is one of the highest incidences worldwide. In Kyrgyzstan, the currently used diagnostic tests in humans and animals are the Rose Bengal Test and the Huddleson test. A national representative cross-sectional study using cluster sampling proportional to size in humans, cattle, sheep, and goats was undertaken to assess the apparent seroprevalence in humans and animals. A total of 4,936 livestock sera and 1,774 human sera were tested in Naryn, Chuy, and Osh Oblasts. The overall apparent seroprevalences of brucellosis were 8.8% in humans (95% CI 4.5-16.5), 2.8% (95% CI 1.6-4.9%) in cattle, 3.3% (95% CI 1.5-6.9%) in sheep, and 2.5% (95% CI 1.4-4.5%) in goats. Naryn Oblast had the highest seroprevalences in humans and sheep. More men than women were seropositive (OR = 1.96; P < 0.001). Human seroprevalence was significantly associated with small ruminant seroprevalence but not with cattle seroprevalence. Annual incidence of human brucellosis exposure, measured by serological tests, was more than ten times higher than the annual incidence of reported clinical brucellosis cases. This indicates an under-reporting of human brucellosis cases, even if only a fraction of seropositive people have clinical symptoms. In conclusion, this study confirms the high seroprevalence of brucellosis in Kyrgyzstan and warrants rapid effective intervention, among others, by mass vaccination of sheep and goats but also of cattle.