Differential metabolism of geometrical isomers of N-nitroso-2,6-dimethylmorpholine in the hamster.
Differential metabolism of geometrical isomers of N-nitroso-2,6-dimethylmorpholine in the hamster.
复制标题
N-亚硝基-2,6-二甲基吗啉几何异构体在仓鼠体内的差异代谢。
DOI：
10.3109/00498257809070028
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
R. Kupper
中科院分区：
文献类型：
--
作者：
R. Gingell;D. Nagel;R. Kupper
1.胰腺癌原N-亚硝基-2，6-二甲基吗啉的顺式和反式异构体已分别制备，并在叙利亚仓鼠中研究了它们的代谢。2.两种异构体均通过β-氧化和开环代谢为N-亚硝基（2-羟丙基）（2-氧代丙基）胺（建议的最接近胰腺致癌物）和N-亚硝基双（2-羟丙基）胺。3.顺式异构体的β-氧化和尿排泄的初始速率比反式异构体大得多，这可以用酶轴向攻击相对容易来解释。然而，24小时尿液中的代谢物量相似。4.结果表明，这两种异构体对仓鼠胰腺的致癌效力没有差异。
1. The cis and trans isomers of the pancreatic carcinogen N-nitroso-2,6-dimethylmorpholine have been prepared separately, and their metabolism studied in the Syrian hamster. 2. Both isomers were metabolized by beta-oxidation and ring scission to N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine, the suggested proximate pancreatic carcinogen, and to N-nitrosobis(2-hydroxypropyl)amine. 3. The initial rate of beta-oxidation and urinary excretion of the cis isomer was much greater than for the trans isomer, and this is explained in terms of relative ease of enzymic axial attack. The amounts of metabolites in the 24-h urine were, however, similar. 4. The results suggest that the two isomers would have no different carcinogenic potency with respect to the hamster pancreas.