The origin of the biphasic flow response to local heat in skin.
The origin of the biphasic flow response to local heat in skin.
复制标题
双相流对皮肤局部热量响应的起源。
DOI：
10.1080/10739680701745388
复制
发表时间：
2008
期刊：
影响因子：
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通讯作者：
Quick,ChristopherM
中科院分区：
文献类型：
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作者：
Widmer,RJay;Laurinec,JenniferE;Young,MissyF;Mohiuddin,MWaqar;Laine,GlenA;Quick,ChristopherM
Objective: Although it is well established that the application of local heat causes a biphasic increase in skin blood flow, the responsible microvessels have not been identified.Methods: A bifurcating network of arterioles (1st–5th orders, 60–15 μm,n= 10 per group) of the intact, unanesthetized, translucent bat wing were visualized on a transparent heat plate via intravital microscopy. Similar to previous bat wing studies, plate temperature was set at 25°C for 10 min then increased to 37°C for 20 min. Vessel diameter and red blood cell velocity were recorded and used to calculate resistance and blood flow.Results: The average flow response in arterioles was biphasic (p= 0.02) and proportional to the temporal decrease in total resistance calculated from 1st–5th order arterioles. Metarteriole (i.e., 5th order arteriole) resistance had the greatest impact on total resistance (−67.0 ± 20.7%) and exhibited a biphasic trend that was opposed by temporal changes in resistance of 1st–4th order arterioles.Conclusion: Metarterioles are not only necessary but sufficient to explain the origin of the biphasic flow response in skin blood flow.
