A strategy for the covalent functionalization of resorbable polymers with heparin and osteoinductive growth factor
A strategy for the covalent functionalization of resorbable polymers with heparin and osteoinductive growth factor
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DOI：
10.1021/bm701267u
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发表时间：
2008-03-01
影响因子：
6.2
通讯作者：
Albertsson, Ann-Christine
中科院分区：
文献类型：
--
作者：
Edlund, Ulrica;Danmark, Staffan;Albertsson, Ann-Christine
本文提出的化学策略是用共价键合到表面的肝素和固定在肝素层中的骨诱导生长因子重组人骨形态发生蛋白-2无损制备可吸收聚合物支架。耦合方案涉及通过在气相中接枝聚（L-丙交酯）和聚（ε-己内酯）膜作为代表性基材的表面功能化。功能化表面的生物相容性通过间充质干细胞（MSC）的附着和增殖的大大改善来验证。
The chemical strategy presented herein is the nondestructive preparation of resorbable polymer scaffolds with heparin covalently bonded to the surface and an osteoinductive growth factor, recombinant human bone morphogenetic protein-2, immobilized in the heparin layer. The coupling scheme involves functionalization of surfaces by grafting in the vapor phase with poly(L-lactide) and poly (e-caprolactone) films chosen as representative substrates. The biocompatibility of functionalized surfaces was verified by a much improved attachment and proliferation of mesenchymal stem cells (MSC).