Antibacterial Activity of CNT-Ag and GO-Ag Nanocomposites Against Gram-negative and Gram-positive Bacteria
Antibacterial Activity of CNT-Ag and GO-Ag Nanocomposites Against Gram-negative and Gram-positive Bacteria
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DOI：
10.5012/bkcs.2013.34.11.3261
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发表时间：
2013-11
影响因子：
1.7
通讯作者：
Hyosuk Yun;J. Kim;H. Choi;C. Lee
中科院分区：
文献类型：
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作者：
Hyosuk Yun;J. Kim;H. Choi;C. Lee
电子邮件：chc12@chonnam.ac.kr（H. C. Choi）; cwlee@jnu.ac.kr（C. W. Lee）2013年7月4日接收，2013年8月9日接受由碳纳米结构和金属纳米颗粒组成的碳纳米复合材料已成为各种应用的有用材料之一。本文主要介绍了碳纳米管-银和GO-Ag纳米复合材料的制备及其抗菌活性。通过TEM、XPS和拉曼光谱表征了它们的物理性能，结果表明，纳米银颗粒以近似球形的形式固定在碳纳米管和石墨氧化物的表面。采用生长曲线法和最小抑菌浓度法研究了CNT-Ag和GO-Ag对革兰氏阴性菌和革兰氏阳性菌的抗菌活性。碳纳米复合材料对革兰氏阳性菌和革兰氏阴性菌的抗菌活性略有不同。关键词：碳纳米结构，银纳米颗粒，抗菌活性，革兰氏阴性菌，革兰氏阳性菌引言抗生素耐药性是公共卫生领域一个严重且日益严重的现象，也是药学和医学领域的一个重大课题.耐药致病菌株的出现速度远远超过了新抗生素开发的速度。因此，迫切需要与现有抗生素相比具有不同作用机制的新型抗生素。在抗生素的研究领域中，开发或寻找对多重耐药（multidrug-resistant，MDR）的人类病原微生物具有改善或独特抗菌活性的抗菌化合物是一个主要的目的。
E-mail: chc12@chonnam.ac.kr (H. C. Choi); cwlee@jnu.ac.kr (C. W. Lee)Received July 4, 2013, Accepted August 9, 2013Carbon nanocomposites composed of carbon nanostructures and metal nanoparticles have become one ofuseful materials for various applications. Here we present the preparation and antibacterial activity of CNT-Agand GO-Ag nanocomposites. Their physical properties were characterized by TEM, XPS, and Ramanmeasurements, revealing that size-similar and quasi-spherical Ag nanoparticles were anchored to the surfaceof the CNT and GO. The antibacterial activities of CNT-Ag and GO-Ag were investigated using the growthcurve method and minimal inhibitory concentrations against Gram-negative and Gram-positive bacteria. Theantibacterial activities of the carbon nanocomposites were slightly different against Gram-positive and Gram-negative bacteria. The proposed mechanism was discussed.Key Words : Carbon nanostructures, Ag nanoparticles, Antibacterial activity, Gram-negative, Gram-positiveIntroductionAntibiotic resistance is a serious and growing phen-omenon in public health and a big task in the field ofpharmaceutical and medicine. Resistant pathogenic strainsare emerging at a rate that far exceeds the speed of newantibiotic development. Therefore, the novel class of anti-biotics having different mechanism of action in comparisonto existing antibiotics is urgently needed. In the research areaof antibiotics, development or searching of the antimicrobialcompounds having improved or distinct antibacterial activityagainst multidrug-resistant (MDR) human pathogenic micro-bes is a primary intention.