URINARY EXCRETION OF FOLATE IN PREGNANCY
URINARY EXCRETION OF FOLATE IN PREGNANCY
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怀孕期间叶酸的尿液排泄
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
A. F. Fleming
中科院分区：
文献类型：
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作者：
A. F. Fleming
本文研究了11名未怀孕妇女和37名怀孕健康妇女内源性血清肌酐和叶酸的血浆清除率。孕妇肾脏对肌酐的平均清除率高出50%，对叶酸的平均清除率高出100%。肌酐和叶酸清除率的增加是独立的，有观点认为，尿中叶酸流失的增加可能是肾小管功能改变的结果，而不是肾小球滤过率的增加。
The plasma clearance rates of endogenous serum creatinine and folate were studied in 11 non‐pregnant and 37 pregnant healthy women. The mean clearance of creatinine by the kidney was about 50 per cent higher and the mean folate clearance over 100 per cent higher in the pregnant women. Creatinine and folate clearance increased independently and it is argued that the greater urinary loss of folate was probably the result of altered renal tubular function, not increased glomerular filtration rate.