Mutagenicity testing of 2,3,7,8-tetrachlordibenzo-p-dioxin in histidine auxotrophs of Salmonella typhimurium.
Mutagenicity testing of 2,3,7,8-tetrachlordibenzo-p-dioxin in histidine auxotrophs of Salmonella typhimurium.
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鼠伤寒沙门氏菌组氨酸营养缺陷型 2,3,7,8-四氯二苯并-对-二恶英的致突变性测试。
DOI：
10.1016/0041-008x(81)90459-2
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发表时间：
1981
影响因子：
3.8
通讯作者：
Neal,RA
中科院分区：
文献类型：
--
作者：
Geiger,LE;Neal,RA
使用鼠伤寒沙门氏菌组氨酸营养缺陷型菌株TA 1535、TA 100、TA 1538、TA 98和TA 1537检测了2，3，7，8-四氯二苯并-对-二恶英（TCDD）的致突变性。在从Arochlor 1254处理的大鼠、Arochlor 1254处理的仓鼠或TCDD处理的仓鼠的肝脏中分离的哺乳动物代谢活化系统存在下，TCDD在任何这些营养缺陷型中均未显示出致突变性。在不存在NADP+依赖性代谢活化的情况下进行的试验未能显示TCDD的任何致突变活性。
The mutagenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been examined using the Salmonella typhimurium histidine auxotrophs TA1535, TA100, TA1538, TA98, and TA1537. TCDD did not show mutagenicity in any of these auxotrophs in the presence of mammalian metabolic activating systems isolated from the livers of Arochlor 1254-treated rats, Arochlor 1254-treated hamsters, or TCDD-treated hamsters. Test run in the absence of NADP+-dependent metabolic activation failed to reveal any mutagenic activity of TCDD.