The Asymmetric Synthesis of (R,R)-Formoterol via Transfer Hydrogenation with Polyethylene Glycol Bound Rh Catalyst in PEG2000 and Water
The Asymmetric Synthesis of (R,R)-Formoterol via Transfer Hydrogenation with Polyethylene Glycol Bound Rh Catalyst in PEG2000 and Water
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DOI：
10.1002/chir.20728
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发表时间：
2010-02-01
期刊：
影响因子：
2
通讯作者：
Li, Xingshu
中科院分区：
文献类型：
--
作者：
Huang, Ling;Liu, Juntao;Li, Xingshu
(R,R)-formoterol was synthesized in seven steps with 4-hydroxyl-3-nitro-acetophenone as the starting material. The key intermediate, the chiral secondary alcohol 4, was prepared via Rh-catalyzed asymmetric transfer hydrogenation with (S,S)-PEGBsDPEN as the ligand and sodium formate as the hydrogen donor under mild conditions. With a mixture of PEG 2000 and water as the reaction media, the catalyst system could be recycled four times. Chirality 22:206-211, 2010. (C) 2009 Wiley-Liss, Inc.
