Expression of E-cadherin adhesion molecule in vocal cord carcinomas
Expression of E-cadherin adhesion molecule in vocal cord carcinomas
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DOI：
10.1007/bf02439971
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发表时间：
1997-11-01
影响因子：
2.6
通讯作者：
Remacle, M
中科院分区：
文献类型：
--
作者：
Liu, M;Lawson, G;Remacle, M
E-钙粘蛋白是一种120 kDa的跨膜蛋白，在维持上皮组织中的细胞-细胞粘附中起主要作用。在本研究中，它的表达进行了检查，首次使用石蜡包埋的档案组织的38声带癌组织化学。10例声带息肉作为阳性对照。根据我们的标准，结果显示，除了一个染色丢失的息肉外，所有息肉都有强或中等的E-钙粘蛋白表达，而32%的肿瘤病例显示染色保留，68%的病例显示染色减少。E-cadherin的表达与组织学分期显著相关，原位癌和微浸润癌中E-cadherin的表达高于浸润癌（P = 0.010）。E-cadherin表达与肿瘤分化程度相关（P = 0.018）。其中一些发现与先前发表的使用新鲜组织的数据一致。我们的研究提供了证据表明，E-钙粘蛋白可能与喉癌的进展和分化，并可能在这种癌症中发挥肿瘤抑制基因的作用。
E-cadherin is a 120 kDa transmembrane protein that plays a major role in the maintenance of cell-cell adhesion in epithelial tissues. In the present study its expression was examined immunohistochemically for the first time using paraffin-embedded archival tissues of 38 vocal cord carcinomas. Ten cases of vocal cord polyps were used as positive controls. According to our criteria, results showed that all but one of the polyps, in which staining was lost, had strong or moderate E-cadherin expression, whereas 32% of the cases with tumors showed preserved staining, and 68% of cases showed a reduced staining. E-cadherin expression was significantly correlated with histological stages, with a greater expression in carcinoma in situ and microinvasive carcinoma than in invasive carcinoma (P = 0.010). A significant correlation was also found between E-cadherin expression and the degree of tumor differentiation (P = 0.018). Some of these findings were consistent with previously published data using fresh tissues. Our study provides evidence that E-cadherin may be linked to progression and differentiation of laryngeal cancer and could play a role as a tumor-suppressor gene in this cancer.